Effectiveness of Plasmapharesis procedure in Yellow Phosphorus Poisoning Patients(Eg: Ratol Poisoning)

Not yet recruiting

Conditions: Toxic effect of phosphorus and itscompounds,

Registration Number: CTRI/2023/01/048821

Lead Sponsor: KMC Manipal

Brief Summary: The study involves the comparison of

standard treatment in yellow phosphorus poisoning with that of Therapeutic Plasma Exchange

(TPE). This is a prospective observational study being conducted for 2 years from August 2022 to

July 2024. All the permissions and clearances will be obtained before starting the study. Consent

will be taken from every patient included in the study. Approximately 46 cases adhering to the

selection criteria are taken for the study and routine lab investigations that are sent as standard

of care will be observed serially. The treatment protocol that is initiated for every patient will be

observed. No audio/video recording is involved in this study and the study involves only

thorough examination of the patient and routine investigation (CBC, RFT, LFT, PT/INR, USG

Abdomen, HBsAg, Anti-HCV). All the patients who are selected for the study will be classified

into different groups based on the treatment that they undergo (standard/TPE). No additional

tests are done. Patients will be followed up for upto 90 days. Data collection is by taking proper

clinical details, history, relevant investigations and entering them into predesigned proforma.

The outcome will then be compared in the two groups in terms of duration of hospital stay,

need for renal dialysis, comparison of clinical improvement and improvement of lab parameters

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 46

Inclusion Criteria

Have consumed yellow phosphorus poison.

Exclusion Criteria

Underlying CLD Mixture of poison Leaving against medical advice Use of hepatotoxic drugs Patients opting for liver transplant Patients with viral hepatitis Coagulation disorders/ on anticoagulants Pregnant mothers.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare the outcome in patients on Standard treatment regimen with Standard+TPE	90 days
To compare the duration of hospital stay in above group of patients	90 days
To compare the need for dialysis in above group of patients	90 days
To compare the outcome in patients who meet and do not meet KCHC criteria	90 days

Secondary Outcome Measures

Name	Time	Method
TPE may act as bridge therapy to liver transplantation in patients with yellow phosphorus poisoning	90 days

Trial Locations

Locations (1): Kasturba Hospital, Manipal
🇮🇳
Udupi, KARNATAKA, India
Kasturba Hospital, Manipal
🇮🇳Udupi, KARNATAKA, India
Mohammed Naif Damudi
Principal investigator
9945169621
mohammed.damudi1@learner.manipal.edu