Evaluation of Breast Cancer Surgical Margins Using Optical Spectroscopy
Not Applicable
Completed
- Conditions
- Breast Cancer
- Registration Number
- NCT00214292
- Lead Sponsor
- University of Wisconsin, Madison
- Brief Summary
This study will apply optical spectroscopy to intraoperative margin assessment during surgery for breast cancer. We hypothesize that a combination of fluorescence spectroscopy and diffuse reflectance spectroscopy will reliably detect involved surgical margins. Twenty patients with ductal carcinoma in-situ will undergo a standard lumpectomy followed by scanning with a sterile optical spectroscopy probe. Frozen sections from the surgical cavity will be used to evaluate the margins. Optical spectroscopy data will be categorized as benign or malignant using a statistical algorithm and the results will be compared with the frozen and permanent section results.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
- ductal carcinoma in-situ or invasive carcinoma diagnosed by image directed core biopsy who are planning to undergo breast conserving surgery
Exclusion Criteria
- patients who were diagnosed with excisional biopsy and patients undergoing mastectomy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method The goal of this research is to develop a minimally invasive technology with the capability of rapidly assessing surgical margins for breast cancer patients undergoing breast conserving therapy.
- Secondary Outcome Measures
Name Time Method 1. Decreasing operative times by eliminating the need to wait for histologic margin assessment. Two potential benefits from developing this technology are: 2 Intraoperative margin assessment will become available for surgeons performing breast conserving therapy in facilities in-house pathologists.
Trial Locations
- Locations (1)
University of Wisconsin
🇺🇸Madison, Wisconsin, United States