Outcomes of RV Dysfunction in Acute Exacerbation of Chronic Respiratory Diseases

• Conditions: Acute Exacerbation of COPD; Acute Exacerbation of Bronchiectasis; Interstitial Lung Disease; Obesity Hypoventilation Syndrome; Acute Exacerbation of Asthma; Neuromuscular Diseases; Acute Respiratory Failure

• Registration Number: NCT04098094
• Lead Sponsor: Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Brief Summary

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure. The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Detailed Description

Observational study in patients with chronic respiratory diseases (chronic obstructive pulmonary diseases, bronchiectasis, interstitial lung diseases, neuromuscular diseases, obesity-hypoventilation syndrome...) admitted in intensive care unit for acute respiratory failure.

Inclusion Criteria:

* Chronic respiratory disease (COPD, ILD, OHS...)

* Admission in ICU for acute respiratory failure

* Patient's non-opposition

Exclusion Criteria:

* Patients \< 18 year-old

* Protected patients

* Pregnant women The main objective is to determine the prevalence of right ventricular (RV) dysfunction in this population and to analyze the impact of such a complication on outcomes (survival at day-28, duration of non-invasive or mechanical ventilation, duration of hospital stay). RV function will be assessed by echocardiography at admission, after 3 days and at discharge. Plasma NT-proBNP and troponin levels will be collected.

Study Timeline

• Study Start: 2019-09-19
• Study First Submitted: 2019-09-19
• Study First Submitted QC: 2019-09-19
• Study First Posted: 2019-09-23
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-17
• Last Update Posted: 2022-02-18
• Primary Completion: 2022-10-30
• Study Completion: 2022-10-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Chronic respiratory disease (COPD, ILD, OHS...)
• Admission in ICU for acute respiratory failure
• Patient's non-opposition

Exclusion Criteria

• Patients < 18 year-old
• Protected patients
• Pregnant women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Survival	Day 28	Survival at day 28

Secondary Outcome Measures

Name	Time	Method
Duration of ventilation	Day 28	Duration of non-invasive ventilation and/or mechanical ventilation

Trial Locations

Locations (1)

Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié Salpêtrière Paris, France; 🇫🇷 Paris, France