Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study

Recruiting

• Conditions: Lung Cancer; Lung Cancer Screening; Patient Empowerment

• Registration Number: NCT05645731
• Lead Sponsor: Nicole Ezer, MD, FRCPC, MPH

Brief Summary

Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival. Risk of developing lung cancer is higher among family members and close contacts of lung cancer patients, because of shared genetics, environment and life habits like smoking. The investigators want to engage lung cancer patients to refer their family members and close contacts for lung cancer screening, and evaluate if this referred population have higher risk of lung cancer than the population referred by their family doctors.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-12-01
• Study First Submitted QC: 2022-12-08
• Study First Posted: 2022-12-09
• Study Start: 2023-05-12
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-13
• Last Update Posted: 2024-03-15
• Primary Completion: 2024-04
• Study Completion: 2025-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• > 18 years old
• Current or former lung cancer patient

Exclusion Criteria

none

Referred participants Inclusion criteria: >18 years old Exclusion criteria: Personal history of lung cancer.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean number of referrals for lung cancer screening per participants	2 weeks post inclusion	Mean number of referrals for lung cancer screening per participants: lung cancer participants will refer contacts directly on the REDCap questionnaire at enrollment. They will be contacted a second time 2 weeks after enrollment and asked if they referred additional people in their entourage for lung cancer screening.
Mean PLCOm2012 risk prediction model score among referred participants	baseline	Mean risk of developing lung cancer in the next 6 years using the validated PLCOm2012 risk prediction model in smokers or ex-smokers referred participants that are 55 to 74 years old.

Secondary Outcome Measures

Name	Time	Method
Anxiety regarding lung cancer for referred participants	1 month	GAD7
Number of visitors on our website for referred participants	6 months	Quantification of people who visited the website for close contacts of lung cancer patients: Number of unique access to website based on google analytics data.
Number of people who started to fill the enrollment form for referred participants.	6 months	Number of people who started to fill the enrollment form for referred participants.
PLCO score as a binary outcome (above or below 2%) among referred participants	baseline
Number of referred participants who enrolled in the study.	6 months	Number of referred participants who enrolled in the study.
Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient	18 months	Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient
Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk.	baseline	Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk.
Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers	baseline	Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers

Trial Locations

Locations (1)

MUHC; 🇨🇦 Montréal, Quebec, Canada