Lung Cancer Screening in Family Members and Peers of Lung Cancer Patients: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Mean number of referrals for lung cancer screening per participants
研究概览
简要总结
Lung cancer screening of active or former heavy smokers with yearly low-dose CT allows for earlier diagnosis and better lung cancer survival. Risk of developing lung cancer is higher among family members and close contacts of lung cancer patients, because of shared genetics, environment and life habits like smoking. The investigators want to engage lung cancer patients to refer their family members and close contacts for lung cancer screening, and evaluate if this referred population have higher risk of lung cancer than the population referred by their family doctors.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •> 18 years old
- •Current or former lung cancer patient
排除标准
- •Referred participants Inclusion criteria: >18 years old Exclusion criteria: Personal history of lung cancer.
结局指标
主要结局
Mean number of referrals for lung cancer screening per participants
时间窗: 2 weeks post inclusion
Mean number of referrals for lung cancer screening per participants: lung cancer participants will refer contacts directly on the REDCap questionnaire at enrollment. They will be contacted a second time 2 weeks after enrollment and asked if they referred additional people in their entourage for lung cancer screening.
Mean PLCOm2012 risk prediction model score among referred participants
时间窗: baseline
Mean risk of developing lung cancer in the next 6 years using the validated PLCOm2012 risk prediction model in smokers or ex-smokers referred participants that are 55 to 74 years old.
次要结局
- Number of visitors on our website for referred participants(6 months)
- Number of people who started to fill the enrollment form for referred participants.(6 months)
- PLCO score as a binary outcome (above or below 2%) among referred participants(baseline)
- Number of referred participants who enrolled in the study.(6 months)
- Proportion of LCS eligible participants who will complete lung cancer screening within 18 months of referral by a lung cancer patient(18 months)
- Proportion of individuals who would theoretically demonstrate interest in genetic testing to assess for lung cancer risk.(baseline)
- Proportion of individuals who demonstrate interest in referral to a smoking cessation program among referred participants that are current smokers(baseline)
- Anxiety regarding lung cancer for referred participants(1 month)
研究者
Nicole Ezer, MD, FRCPC, MPH
Assistant professor of medicine
McGill University Health Centre/Research Institute of the McGill University Health Centre