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临床试验/NCT03481257
NCT03481257已完成不适用

Comparison of Shear Stress-induced Thrombotic and Thrombolytic Effect d Thrombolytic Effect Between Ticagrelor Versus Very Low Dose Rivaroxaban With Clopidogrel in Patients With Acute Coronary Syndrome

Seoul National University Hospital1 个研究点 分布在 1 个国家目标入组 56 人开始时间: 2017年4月12日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
56
试验地点
1
主要终点
Occlusion time

研究概览

简要总结

A total of 50 participants diagnosed with ACS (group A ticagrelor 180mg/d, n=25), group B (clopidogrel 75mg + rivaroxaban 5mg/ d, n=25)) were consecutively enrolled and treated with study drugs on top of aspirin (100mg/d) for 1 month. VerifyNow® and Global thrombosis test were performed at day 2 and 1 month after administration of study drugs. The investigators compared aspirin reaction unit (ARU) and P2Y12 reaction unit (PRU), occlusion time (OT) which reflects shear stress-induced thrombotic activity, and lysis time (LT) which showed endogenous lytic activity between the two strategies at both time points.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients who were diagnosed with acute coronary syndrome and underwent percutaneous coronary intervention

排除标准

  • Patients administered with glycoprotein IIb/IIIa inhibitiors
  • Patients with atrial fibrillation
  • Patients with high risk of bleeding at the physician's discretion
  • Patients with renal impairment (estimated GFR <30ml/min)

结局指标

主要结局

Occlusion time

时间窗: 1 month

Global thrombosis test

次要结局

  • Aspirin reaction unit(Day 2 and 1 month)
  • Lysis time(Day 2)
  • Occlusion time(Day 2)
  • P2Y12 reaction unit(Day 2 and 1 month)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Jung-Won Suh

Principal Investigator

Seoul National University Hospital

研究点 (1)

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