The Effects of MDMA on Sleep Architecture, Water Homeostasis and Cognitive Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Time course, severity, and characteristics of MDMA discontinuation in experienced MDMA users given a known dose of MDMA
研究概览
简要总结
The purpose of this study is to measure the effects of MDMA on sleep, mood, thinking, and how your body retains water. The researchers are interested in the effects that occur a few hours after taking MDMA as well as effects occurring over the next two days. We will study these effects in a standardized, controlled setting at the Clinical and Translational Science Institute (CTSI) Clinical Research Center (CRC) located at San Francisco General Hospital.
The primary hypotheses are:
- MDMA will induce sleep disruption, as indicated by comprehensive polysomnography, wrist actigraphy, and self-report sleep measures
- MDMA will alter sodium and water homeostasis by either increasing or blunting the suppression of arginine vasopressin levels and decreasing free water excretion. Effects will be exacerbated by water loading.
Secondary hypotheses:
- Acutely, MDMA will increase both positive and negative arousal, and to increase sociability but not autonomy.
- Acutely, MDMA will increase risk-taking and willingness to donate money to others in an economic decision making task.
- MDMA will decrease the stressful effects of talking about a negatively-valenced autobiographical but will increase recall for details for these episodes.
- MDMA will increase oxidative stress markers and possible ameliorating factors (e.g., ADMA).
- The short form of the serotonin transported promoter region will be associated with greater acute and discontinuation effects of MDMA.
详细描述
This is a placebo-controlled, double-blind, gender balanced, within-subject study on the acute and 24 to 48 hour post dose effects (discontinuation syndrome) of MDMA on sleep architecture, water homeostasis and neurocognitive function. We will define the signs and symptoms of sleep disruption and time course of alterations in ADH levels and neurocognitive function occurring after administration of a single dose of MDMA in experienced users. The immediate effects of MDMA include euphoria and intoxication; at 24 hours after MDMA these positive effects are replaced by lowered mood and lethargy - we refer to these effects as a discontinuation syndrome. The pleasurable effects of MDMA are thought to be due to elevations of serotonin, norepinephrine and dopamine; the mechanisms of post-MDMA depression are unknown but may be due to relative serotonin depletion. Among its many functions serotonin maintains normal sleep architecture. The effects of MDMA discontinuation on sleep architecture will be assessed using comprehensive polysomnography and wrist actigraphy with measures obtained ~36 hours after a single dose of MDMA. Cognitive measurements will explore the acute effects of MDMA. MDMA can produce hyponatremia. In this study we will evaluate the effects of MDMA on ADH release, urine sodium excretion, and the relationship of gender to these effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men or women aged 18 to 50 years.
- •If female: abstains from heterosexual sex, not of childbearing potential, or reports using an approved contraceptive.
- •Experienced with MDMA
- •Fluent in English.
- •Willing and able to give written consent.
- •Healthy without medical contraindications to MDMA administration determined by the following: medical history, physical examination, 12-lead EKG, hematology, blood chemistry, and urinalysis.
- •Blood liver transaminase elevations up to 3 times the upper limit of normal.
- •If female: negative pregnancy test at screening and at the beginning of each hospital admission.
- •Negative urine drug test at screening and prior to each potential MDMA administration.
排除标准
- •Current enrollment in a MDMA, alcohol, or other drug treatment program or current legal problems relating to MDMA, alcohol, or other drug use, including awaiting trial or supervision by a parole or probation officer.
- •Participants with a past-history of using only low doses of MDMA
- •Currently trying to quit MDMA use.
- •Current dependence on any other psychoactive drug (including nicotine).
- •Significant physical or psychiatric illness that might impair the ability to safely complete the study or that might be complicated by the study drugs, including prior seizures (after age 8) or other active neurological disease or clinically significant abnormalities on physical examination or screening laboratory values.
- •Likelihood of needing medications to treat an illness during the study period.
- •Body Mass Index > 30 or <
- •HIV seropositive by self-report.
- •If female: pregnancy or lactation.
- •History of serious adverse event or hypersensitivity to MDMA.
- •Currently taking any medication other than over-the-counter non-steroidal anti-inflammatories, topical medications, inhaled asthma therapy, and over-the-counter non-sedating antihistamines.
- •Male neck size ≥ 17 inches, female neck size ≥ 16 inches
- •Modified Mallampati class ≥
- •Recent travel within 3 days to or from a different time zone, other than Mountain Standard Time.
- •Any other medical or psychosocial condition that would preclude useful, safe, or consistent participation.
研究组 & 干预措施
MDMA
干预措施: 3,4-methylenedioxymethamphetamine or Placebo (Drug)
结局指标
主要结局
Time course, severity, and characteristics of MDMA discontinuation in experienced MDMA users given a known dose of MDMA
时间窗: 1 hour post dose through 48 hours post dose
Relate observed discontinuation effects to sleep data: polysomnography, wrist actigraphy, and self-report sleep measures.
时间窗: 1 hour post dose through 48 hours post dose
Assess the acute effects of MDMA on water and sodium homeostasis
时间窗: 1 hour post dose through 48 hours post dose
次要结局
- Document the acute effects of MDMA on self-reported measures, including positive and negative arousal, autonomy, and sociability.(1 hour post dose through 48 hours post dose)
- Document the acute effects of MDMA on behavioral measures of economic decision making.(1 hour post dose through 48 hours post dose)
- Document the acute effects of MDMA on autobiographical speech and memory(1 hour post dose through 48 hours post dose)
- Measure the effects of MDMA on ADMA(1 hour post dose through 48 hours post dose)
研究者
John Mendelson, MD
Senior Scientist
California Pacific Medical Center Research Institute