Iplasma IL6, Procalcitonin and VEGF and Dialysate Level in CAPD Patients

Completed

• Conditions: Chronic Kidney Disease

• Registration Number: NCT02881892
• Lead Sponsor: Bangkok Metropolitan Administration Medical College and Vajira Hospital

Brief Summary

The aim of study was to evaluated the correlation between plasma levels, dialysate appearance rate of VEGF, inflammatory cytokines (IL- 6, procalcitonin) and PSTR, dialysis adequacy in CAPD patients.

Detailed Description

This cross -sectional study measured IL-6, procalcitonin and VEGF level in plasma and overnight effluent. PSTR of small solutes was evaluated by standard peritoneal equilibration test (standard PET). Weekly Kt/V and creatinine clearance (CCr ) were evaluated in all patients.

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2014-05
• Study Completion: 2014-06
• Status Verified: 2016-08
• Study First Submitted: 2016-08-18
• Study First Submitted QC: 2016-08-26
• Last Update Submitted: 2016-08-26
• Study First Posted: 2016-08-29
• Last Update Posted: 2016-08-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• Stable CAPD patients without previous history of peritonitis

Exclusion Criteria

• HIV
• Other infections, tuberculosis or on immunosuppressive drugs,
• Autoimmune disease,
• Cancer
• Diagnosis of permanent ultrafiltration failure .

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
plasma level of VEGF, IL-6 and procalcitonin with the PSTR and dialysis adequacy in CAPD patients	2 years	measure in pg/ml

Secondary Outcome Measures

Name	Time	Method
Cytokines in diabetic and non-diabetic group	2 years	All cytokines in plasma and blood

Trial Locations

Locations (1)

Renal Unit, BMA Medical College and Vajira Hospital; 🇹🇭 Bangkok, Thailand