NCT04308486Unknown不适用
Anti-mullerian Hormone,Testesterone,Esrtadiol,Testesterone/Esrtadiol Ratio as Predictive Values for TESA and TESE Outcome in Non Obstructive Azoospermia
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 主要终点
- Evaluate the predictive value of Anti-mullerian hormone,Testosterone,Estradiol,Testosterone/Estradiol ratio for TESA and TESE outcome in non obstructive azoospermia
研究概览
简要总结
*Evaluate the predictive value of AMH, Testosterone,Estradiol,Testosterone Estradiol ratio for TESA and TESE outcome in non obstructive azoospermic patients.
详细描述
- The relevance of male infertility has progressively grown , with significant medical, psychological, and socio-economic implications. .. With no sperm found at multiple semen analyses, non-obstructive azoospermia (NOA) is the most severe form of infertility.
- The introduction to clinical practice of assisted reproduction techniques such as intra-cytoplasmic sperm injection (ICSI) made fatherhood possible for men with (NOA). The extraction of sperm from the testis through testicular sperm aspiration (TESA), testicular sperm extraction (TESE) or open biopsy can result in a favorable reproductive outcome. Nevertheless, all these procedures are invasive in nature with variable possibility of successful sperm extraction. As a consequence, a non-invasive test that could predict the presence of sperm in men with NOA would be of profound clinical importance
- However, the lack of useful predictive biomarkers suggestive for successful sperm retrieval at microTESE and TESA in NOA men still represents a relevant gap with a very negative return for the patient. Indeed, no significant association has been found between microTESEand TESA sperm retrieval outcomes and preoperative testicular volume, baseline follicular stimulating hormone (FSH) levels, basal level of Testosterone (T) or increased T level following treatments with aromatase inhibitors, clomiphene citrate or human chorionic gonadotropin.
- Therefore, it has been amust to identify novel and user-friendly prognostic factors reliably predicting surgical outcomes in NOA men in the real-life setting. Among other variables, some hormons can be subjected to studies for this purpose such as levels of testis-derived hormones (which might be representative of the primary testicular failure) as the Anti-Müllerian Hormone (AMH),( which is suggestive for a Sertoli cells' immature phenotype),and testosterone of biological relevance...
- An investigation from the early 1970s demonstrated that the human testis does indeed secrete estradiol within the spermatic vein, at amean concentration that is 50 times greater than that inthe peripheral plasma . These findings led to the hypothesis that local estrogen levels might be associated with the current stateof spermatogenesis, or the total number of spermatogenic cells in the testis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •a clinical diagnosis of NOA associated with primary couple's infertility;
- •age from 20 to 50 years old
- •freedom from any known systemic diseases affecting the previous hormonal levels such as liver cirrhosis .
- •hormonal therapy for at least two weeks prior to the surgery
排除标准
- •obstructive azoospermia
- •congenital bilateral absent vas
结局指标
主要结局
Evaluate the predictive value of Anti-mullerian hormone,Testosterone,Estradiol,Testosterone/Estradiol ratio for TESA and TESE outcome in non obstructive azoospermia
时间窗: baseline
次要结局
未报告次要终点
研究者
Reham Ahmed Ashraf Fakhr Eldeen Hamoda
Doctor
Assiut University
相似试验
已完成
不适用
Evaluation of Anti-mullerian Hormone Levels as Predictive of IVF Outcomes in Women Over 38 Years OldAMH LevelsInhibin B LevelsIVF Patients Over 38 Years OldNCT01219387Reproductive Medicine Associates of New Jersey300
已完成
不适用
Evaluation blood level of anti-m?llerian hormone measurement efficiency in prediction of the response to weight loss diet in obese women with polycystic ovarian syndrome with infertility problem.Obesity in polycystic ovary syndrome women.Polycystic ovarian syndromeIRCT201302241141N14Royan institute80
已完成
不适用
Measurement of Different Anti-Müllerian Hormone Isoforms in Expected Poor RespondersAnti-Mullerian Hormone IsoformsNCT03826888ART Fertility Clinics LLC72
招募中
不适用
A prospective study of antimullerian hormone as a potential predictor of chemotherapy induced menopauseACTRN12611000613909Hilary Martin20
已完成
不适用
Anti-Mullerian Hormone (AMH) is a Marker for Ovarian Reserve. There Are Many Studies About AMH Changes in Ovarian Surgery, But Little is Known for Other Surgeries. We Seek to Investigate the Hormone Variations Before and After Uterine Artey Ligation for Postpartum Hemorrage (PPH)Anti-Mullerian Hormone DeficiencyPost Partum HemorrhageNCT03907605Kanuni Sultan Suleyman Training and Research Hospital88