Efficacy of Strength and Aerobic Exercise on the Articular Cartilage of Patients With Mild and Moderate Knee Osteoarthritis Measured by T2 and T1 Rho MR Imaging - A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 2
- 主要终点
- Qualitative Cartilage Morphology Assessment
研究概览
简要总结
This study is the radiological component of an earlier registered trial under the title: Efficacy of Exercise on Physical Function and Cartilage Health in Patients With Knee Osteoarthritis. The main purpose in this component of the study is to evaluate the efficacy of aerobic exercise and strength training on the T2 and T1 rho relaxation times of the articular cartilage. It has been proven that exercise can improve function and reduce the need for analgesics in patients with osteoarthritis. With this study, we wish to investigate if different kinds of exercise can cause measurable improvements in T2 and T1 rho relaxation times of the articular cartilage, and also if this improvements are transient or permanent.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Women and men aged 45-65 years
- •Clinical knee OA according to the American College of Rheumatology Clinical Criteria 17
- •Kellgren and Lawrence radiographic OA grade 2 and 3 (mild to moderate radiographic OA)
排除标准
- •Severe knee OA according to the Kellgren and Lawrence classification (grade 4)
- •Other known major musculoskeletal impairments in the lower extremities or the back or prostheses in any joint of the lower extremities
- •Known coronary heart diseases or cancer
- •Body mass index > 35
- •Scheduled for surgery in any joint
- •Known mental or psychologic diseases
- •Known drug abuse
- •Persons who already perform sports related moderate physical activity more than two times a week
- •Contraindications for magnetic resonance imaging (specific point list at Diagnostic Imaging Division, Akershus University Hospital)
- •Not speaking Norwegian
结局指标
主要结局
Qualitative Cartilage Morphology Assessment
时间窗: One year
Indirect cartilage morphology will by assessed by X-ray Direct cartilage morphology will be assessed by MRI morphometry The biochemical composition of the cartilage will be assessed by relaxometry (T2 and T1 rho relaxation times)
次要结局
- Semiquantitative Cartilage Assessment(One year)
研究者
Hasan Banitalebi
Radiologist
University Hospital, Akershus