Efficacy of Platelet Rich Plasma Injections in Patients With Adhesive Capsulitis of the Shoulder
Overview
- Phase
- Early Phase 1
- Intervention
- Not specified
- Conditions
- Adhesive Capsulitis of Shoulder
- Sponsor
- Ege University
- Enrollment
- 32
- Primary Endpoint
- Shoulder Pain and Disability Index (SPADI)
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
This study was done to investigate whether platelet rich plasma(PRP) injections are effective in the management of adhesive capsulitis of the shoulder(AC).Patients were randomized to 2 groups, and one group took PRP injections for 3 times every two weeks, while the other group took saline injections in same frequency and volume. A standardized exercise programme was also applied to all patients.
Patients were then evaluated with Shoulder Pain and Disability Index(SPADI), Visual analogous scales for pain and disability, Ranges of Movements and use of analgesics in before, after and 3rd month of the therapy.
Investigators
Funda Atamaz Calis
Professor in Ege University School of Medicine
Ege University
Eligibility Criteria
Inclusion Criteria
- •Being over 18 years old and having a shoulder pain with restriction for 3 months at least, and 9 months at most(Pain VAS being \>40 mm, and loss of ROM for affected side more than %25 of unaffected side).
Exclusion Criteria
- •Subjects were excluded if they had uncontrolled diabetes, active inflammatory diseases, ongoing pregnancy, severe anemia, psychiatric diseases that may affect compliance or cancer. Patients who had a history of trauma, recent injection therapies(\<3 months), surgery or allergy to local anaesthetics, or signs of complex regional pain syndrome, local infections or use of non steroidal anti-inflammatory drugs throughout the study were also excluded.
Outcomes
Primary Outcomes
Shoulder Pain and Disability Index (SPADI)
Time Frame: 3 months
Shoulder Pain and Disability Index (SPADI) is a tool to assess pain and disability in patients with shoulder pain, which was extensively used in studies involving AC of the shoulder6, 15, 16. It consists of 5 questions in pain domain, and 8 questions in disability domain, which were expressed in a visual analogous scale.
Visual Analogous Scales for pain
Time Frame: 3 months
Patients were asked to describe their pain, level of disability or treatment satisfaction on a 10 cm long line, with 0 point being "none", and 10 cm point being "highest possible". The proximity of the marked point to the 0 end was measured, and the results were recorded
Secondary Outcomes
- Visual Analogous Scales for disability(3 months)
- Analgesic use(3 months)
- Shoulder ranges of motions(3 months)