Neutrophil Gelatinase Associated Lipocalin (NGAL) in Urine: Can This Prove to be a Biomarker for Acute Kidney Injury in Patients With Sepsis?

Completed

• Conditions: Septic Shock; Acute Kidney Injury; Severe Sepsis

• Registration Number: NCT02034240
• Lead Sponsor: Sygehus Lillebaelt

Brief Summary

Patients with severe infection and sepsis are in high risk of hypo perfusion and therefore organ affection. Temporary or permanent kidney failure is a common complication in these patients. Today's golden standard for kidney failure detection is creatinine levels rising and / or oliguria. The investigators hypothesize that an even more sensitive biomarker; neutrophil gelatinase associated lipocalin(NGAL) in urine can predict kidney injury before creatinine levels rise. In recent studies NGAL in urine seem to be a sensitive biomarker in these patient to predict kidney injury, but the time factor for sampling optimally is not known. In this pilot study the investigators sample the urine at admission within the first hour of hospitalization to investigate if NGAL can be used as a predictor in an emergency setting.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-01-07
• Study First Submitted QC: 2014-01-09
• Study First Posted: 2014-01-13
• Status Verified: 2015-04
• Primary Completion: 2015-04
• Study Completion: 2015-04
• Last Update Submitted: 2015-04-19
• Last Update Posted: 2015-04-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Severe sepsis
• Septic shock
• Patients must not be able to give consent

Exclusion Criteria

• Underaged (18 years )
• known kidney injury
• Fully alert patients that can give consent

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of Acute Kidney Failure	During hospitalization, anticipated approximately 5 weeks

Secondary Outcome Measures

Name	Time	Method
Levels of NGAL in patients with kidney failure compared to creatinine	During hospitalization, anticipated approximately 5 weeks

Trial Locations

Locations (1)

Faelles Akut Modtagelse, Kolding Sygehus; 🇩🇰 Kolding, Denmark