Propofol-remifentanil Versus Dexmedetomidine in Awake Craniotomy: an Intraoperative Neurophysiological Evaluation
Overview
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 170
- Locations
- 1
- Primary Endpoint
- SEIZURE ACTIVITY
Overview
Brief Summary
Awake craniotomy require a cooperative patient during resection neurosurgery phase. Anesthesiologist should guarantee analgesia, sedation, nausea and vomiting prevention, while maintaining normal vital parameters.
Neurosurgeon could be help by Intraoperative electrocorticography to maximise lesion resection and avoiding neurologic sequelae. Propofol and remifentanyl have been largely used. Dexmedetomidine represents an alternative. However little is known about the role of dexmedetomidine on Intraoperative electrocorticography.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •PATIENTS UNDERGOING AWAKE CRANIOTOMY FOR TUMOR RESECTION (EXCLUDED E.G. SURGERY OF EPILEPSIA)
- •INTRAOPERATIVE MONITORING (IOM) WITH ELECTROCORTICOGRAPHY
- •AWAKE-AWAKE-AWAKE TECHNIQUE
Exclusion Criteria
- •AGE \<18 YEARS OLD
- •NON AWAKE-AWAKE-AWAKE TECHNIQUE
- •ABSENCE OF IOM
Arms & Interventions
PROPOFOL-REMIFENTANYL
Awake craniotomy under propofol-remifentanil sedation. Propofol and remifentanyl was administered through continuous intravenous infusion, starting 30 minutes prior to surgery. The end of the infusion was at the end of the surgical procedure.
Propofol dosage: 0.2-2 mk/kg/h Remifentanyl dosage: 0.01-0.1 mcg/kg/min
Intervention: Propofol (Drug)
Outcomes
Primary Outcomes
SEIZURE ACTIVITY
Time Frame: DURING TUMOR RESECTION PHASE OF THE AWAKE CRANIOTOMY
INCIDENCE OF ELECTRO-CLINICAL SEIZURE ACTIVITY IN THE TWO GROUPS DURING RESECTIVE PHASE OF AWAKE CRANIOTOMY EVALUATED WITH ELECTROCORTICOGRAPHY.
Secondary Outcomes
No secondary outcomes reported
Investigators
Cristian Deana
Principal Investigator
Azienda Sanitaria-Universitaria Integrata di Udine