Propofol-remifentanil Versus Dexmedetomidine in Awake Craniotomy: an Intraoperative Neurophysiological Evaluation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 170
- 试验地点
- 1
- 主要终点
- SEIZURE ACTIVITY
研究概览
简要总结
Awake craniotomy require a cooperative patient during resection neurosurgery phase. Anesthesiologist should guarantee analgesia, sedation, nausea and vomiting prevention, while maintaining normal vital parameters.
Neurosurgeon could be help by Intraoperative electrocorticography to maximise lesion resection and avoiding neurologic sequelae. Propofol and remifentanyl have been largely used. Dexmedetomidine represents an alternative. However little is known about the role of dexmedetomidine on Intraoperative electrocorticography.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •PATIENTS UNDERGOING AWAKE CRANIOTOMY FOR TUMOR RESECTION (EXCLUDED E.G. SURGERY OF EPILEPSIA)
- •INTRAOPERATIVE MONITORING (IOM) WITH ELECTROCORTICOGRAPHY
- •AWAKE-AWAKE-AWAKE TECHNIQUE
排除标准
- •AGE <18 YEARS OLD
- •NON AWAKE-AWAKE-AWAKE TECHNIQUE
- •ABSENCE OF IOM
研究组 & 干预措施
PROPOFOL-REMIFENTANYL
Awake craniotomy under propofol-remifentanil sedation. Propofol and remifentanyl was administered through continuous intravenous infusion, starting 30 minutes prior to surgery. The end of the infusion was at the end of the surgical procedure.
Propofol dosage: 0.2-2 mk/kg/h Remifentanyl dosage: 0.01-0.1 mcg/kg/min
干预措施: Propofol (Drug)
结局指标
主要结局
SEIZURE ACTIVITY
时间窗: DURING TUMOR RESECTION PHASE OF THE AWAKE CRANIOTOMY
INCIDENCE OF ELECTRO-CLINICAL SEIZURE ACTIVITY IN THE TWO GROUPS DURING RESECTIVE PHASE OF AWAKE CRANIOTOMY EVALUATED WITH ELECTROCORTICOGRAPHY.
次要结局
未报告次要终点
研究者
Cristian Deana
Principal Investigator
Azienda Sanitaria-Universitaria Integrata di Udine