Peripartum Mental Health Cohort Study in Guangzhou
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Change of prevalence of maternal prenatal depression
研究概览
简要总结
The purpose of this study is to determine the incidence,development trajectory and risk factors of the main peripartum mental health problems as well as explore its adverse outcomes.
详细描述
Peripartum mental health problems (such as anxiety and depression), affecting more than 20% of mothers, is one of the most common complications around childbirth and gradually have become global public health issues. However, little is known about the course of peripartum mental health problems and possible fluctuations, as well as related risk factors among Chinese women. In addition, there are no effective prediction and preventive strategies for postpartum depression. The Peripartum Mental Health Cohort Study in Guangzhou will collect the epidemiological, clinical information and biological specimens across pregnancy and childbirth to establish trajectory of peripartum mental health and identify the factors influencing the fluctuations and build a comprehensive prediction model of postpartum depression, as well as explore its adverse outcomes. This study would help to determine the timing of screening and target interventions to improve women's and their offspring's health.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women with <20 weeks of gestation
- •Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
- •Permanent residents or families intended to remain in Guangzhou with their child for more than 3 years
排除标准
- •Combined with heart disease, hypertension, diabetes or hyperthyroidism
- •Taking anti-depressants and other treatments for depression
- •Participants was in infection status when the biological samples were collected
结局指标
主要结局
Change of prevalence of maternal prenatal depression
时间窗: before 20th gestational week, after 33th gestational week and prior to delivery
Using Self-rating Depression Scale (SDS) to assess maternal depressive symptoms during pregnancy. SDS scores ≥53 is defined as prenatal depressive symptoms.
Change of prevalence of maternal postpartum depression in the first year after delivery
时间窗: 6 weeks, 6 months and 1 year after delivery
Using Edinburgh Postnatal Depression Scale (EPDS) to assess postpartum depressive symptoms. EPDS scores ≥13 is defined as postpartum depressive symptoms.
次要结局
- Levels of maternal inflammatory factors during pregnancy(During period of 2-3 trimesters of pregnancy)
- Level of maternal cortisol during pregnancy(During period of 2-3 trimesters of pregnancy)
- Child's neurodevelopment at early childhood(At child's age of 1 year)
- Change of prevalence of maternal anxiety during pregnancy(before 20th gestational week, after 33th gestational week and prior to delivery)
- Prevalence of preterm birth, small for gestational age, low birth weight(At delivery)
研究者
Xiu Qiu
Director of the Born in Guangzhou Cohort Study
Guangzhou Women and Children's Medical Center