Exercise Training Program for Cerebellar Ataxia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 2
- 主要终点
- Change in walking speed from baseline to mid-training and to post-training
研究概览
简要总结
The purpose of this study is to determine whether a person's ability to adapt (i.e. short term motor learning) predicts their ability to benefit from physical therapy exercises.
详细描述
The cerebellum is important for coordination of movement and for motor learning. No medications systematically improve cerebellar ataxia, and little is known about the effectiveness of rehabilitation exercises, which are often the only treatment option. Here, we ask whether a person's ability to adapt (i.e. short term motor learning) predicts their ability to benefit from physical therapy exercises. This pilot-clinical trial will test a subject's ability to adaptively learn a new walking pattern in a single session, and then any improvement of walking and balance over a 13 week time period during which they participate in a specialized home exercise training program. Our prediction is that those individuals with some preserved adaptive learning ability will be the best rehabilitation candidates.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 95 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cerebellar damage from stroke, tumor, or degeneration
- •Able to stand and take steps with or without assistance
- •Age 18-95
排除标准
- •Extrapyramidal symptoms
- •Peripheral vestibular loss (e.g. absence of VOR)
- •Congestive heart failure
- •Peripheral artery disease with claudication
- •Pulmonary or Renal Failure
- •Unstable angina
- •Uncontrolled hypertension ( > 190/100 mmHg)
- •Dementia (Mini-Mental State exam > 22)
- •Severe aphasia
- •Orthopedic or pain conditions
- •Pregnancy
- •Evidence of chronic white matter disease on MRI
结局指标
主要结局
Change in walking speed from baseline to mid-training and to post-training
时间窗: Participants are assessed at baseline (week 1 and week 3), mid-training (week 6), and post-training (week 9 and week 13). There are a total of 13 weeks for this study with 5 visits during that time period
Here, we ask whether a person's ability to adapt (i.e. short term motor learning) predicts their ability to benefit from physical therapy exercises. Our prediction is that those individuals with some preserved adaptive ability will be show the greatest improvement in walking speed.
次要结局
未报告次要终点
研究者
Amy J. Bastian, Ph.D.
Principal Investigator
Hugo W. Moser Research Institute at Kennedy Krieger, Inc.