Docetaxel in Treating Patients With Recurrent or Persistent Endometrial Carcinoma (Cancer)
- Conditions
- Endometrial Cancer
- Registration Number
- NCT00085332
- Lead Sponsor
- Gynecologic Oncology Group
- Brief Summary
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: This phase II trial is studying how well docetaxel works in treating patients with recurrent or persistent endometrial carcinoma (cancer).
- Detailed Description
OBJECTIVES:
* Determine the antitumor activity of docetaxel in patients with recurrent or persistent endometrial carcinoma.
* Determine the toxicity of this drug in these patients.
OUTLINE: This is a multicenter study.
Patients receive docetaxel IV over 1 hour on days 1, 8, and 15. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Patients are followed every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 19-51 patients will be accrued for this study within 10-18 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (75)
CCOP - Geisinger Clinic and Medical Center
🇺🇸Danville, Pennsylvania, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University
🇺🇸Cleveland, Ohio, United States
Cleveland Clinic Taussig Cancer Center
🇺🇸Cleveland, Ohio, United States
Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University
🇺🇸Columbus, Ohio, United States
Abramson Cancer Center of the University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Cancer Center at Tufts - New England Medical Center
🇺🇸Boston, Massachusetts, United States
CCOP - Kansas City
🇺🇸Kansas City, Missouri, United States
CCOP - Christiana Care Health Services
🇺🇸Newark, Delaware, United States
MBCCOP - University of Illinois at Chicago
🇺🇸Chicago, Illinois, United States
MBCCOP - Hawaii
🇺🇸Honolulu, Hawaii, United States
Women's Cancer Center - Los Gatos
🇺🇸Los Gatos, California, United States
CCOP - Carle Cancer Center
🇺🇸Urbana, Illinois, United States
CCOP - Evanston
🇺🇸Evanston, Illinois, United States
Siteman Cancer Center at Barnes-Jewish Hospital
🇺🇸Saint Louis, Missouri, United States
University of Texas Medical Branch
🇺🇸Galveston, Texas, United States
MD Anderson Cancer Center at University of Texas
🇺🇸Houston, Texas, United States
Indiana University Cancer Center
🇺🇸Indianapolis, Indiana, United States
University of Minnesota Cancer Center
🇺🇸Minneapolis, Minnesota, United States
Duke Comprehensive Cancer Center
🇺🇸Durham, North Carolina, United States
Charles M. Barrett Cancer Center at University Hospital
🇺🇸Cincinnati, Ohio, United States
Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center
🇺🇸Nashville, Tennessee, United States
CCOP - Western Regional, Arizona
🇺🇸Phoenix, Arizona, United States
Comprehensive Cancer Center at University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
University of Colorado Cancer Center at University of Colorado Health Sciences Center
🇺🇸Denver, Colorado, United States
University of Oklahoma College of Medicine
🇺🇸Oklahoma City, Oklahoma, United States
CCOP - Columbia River Oncology Program
🇺🇸Portland, Oregon, United States
North Shore University Hospital
🇺🇸Manhasset, New York, United States
Penn State Cancer Institute at Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
CCOP - Michigan Cancer Research Consortium
🇺🇸Ann Arbor, Michigan, United States
Mayo Clinic Cancer Center
🇺🇸Rochester, Minnesota, United States
CCOP - Missouri Valley Cancer Consortium
🇺🇸Omaha, Nebraska, United States
Comprehensive Cancer Center at Wake Forest University
🇺🇸Winston-Salem, North Carolina, United States
Jonsson Comprehensive Cancer Center at UCLA
🇺🇸Los Angeles, California, United States
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
🇺🇸Orange, California, United States
H. Lee Moffitt Cancer Center and Research Institute at University of South Florida
🇺🇸Tampa, Florida, United States
University of Chicago Cancer Research Center
🇺🇸Chicago, Illinois, United States
CCOP - Central Illinois
🇺🇸Decatur, Illinois, United States
Markey Cancer Center at University of Kentucky Chandler Medical Center
🇺🇸Lexington, Kentucky, United States
Saint Joseph Regional Medical Center
🇺🇸South Bend, Indiana, United States
Holden Comprehensive Cancer Center at University of Iowa
🇺🇸Iowa City, Iowa, United States
UMASS Memorial Cancer Center - University Campus
🇺🇸Worcester, Massachusetts, United States
CCOP - Grand Rapids
🇺🇸Grand Rapids, Michigan, United States
CCOP - Kalamazoo
🇺🇸Kalamazoo, Michigan, United States
Keesler Medical Center - Keesler Air Force Base
🇺🇸Keesler AFB, Mississippi, United States
CCOP - Metro-Minnesota
🇺🇸Saint Louis Park, Minnesota, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Ellis Fischel Cancer Center at University of Missouri - Columbia
🇺🇸Columbia, Missouri, United States
Cancer Institute of New Jersey at the Cooper University Hospital
🇺🇸Camden, New Jersey, United States
CCOP - Cancer Research for the Ozarks
🇺🇸Springfield, Missouri, United States
SUNY Downstate Medical Center
🇺🇸Brooklyn, New York, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Memorial Sloan-Kettering Cancer Center
🇺🇸New York, New York, United States
Gynecologic Oncology Network
🇺🇸Greenville, North Carolina, United States
Long Island Cancer Center at Stony Brook University Hospital
🇺🇸Stony Brook, New York, United States
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
UPMC Cancer Center at Magee-Womens Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
Southeast Gynecologic Oncology Associates
🇺🇸Knoxville, Tennessee, United States
Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas
🇺🇸Dallas, Texas, United States
CCOP - Scott and White Hospital
🇺🇸Temple, Texas, United States
Cancer Center at the University of Virginia
🇺🇸Charlottesville, Virginia, United States
Fletcher Allen Health Care - Medical Center Hospital of Vermont Campus
🇺🇸Burlington, Vermont, United States
Fred Hutchinson Cancer Research Center
🇺🇸Seattle, Washington, United States
MultiCare Regional Cancer Center at Tacoma General Hospital
🇺🇸Tacoma, Washington, United States
University of Wisconsin Comprehensive Cancer Center
🇺🇸Madison, Wisconsin, United States
CCOP - Marshfield Clinic Research Foundation
🇺🇸Marshfield, Wisconsin, United States
Australia New Zealand Gynaecological Oncology Trials Group
🇦🇺Camperdown, New South Wales, Australia
Kagoshima City Hospital
🇯🇵Kagoshima City, Japan
Tom Baker Cancer Centre - Calgary
🇨🇦Calgary, Alberta, Canada
Norwegian Radium Hospital
🇳🇴Oslo, Norway
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Yale Comprehensive Cancer Center
🇺🇸New Haven, Connecticut, United States
Walter Reed Army Medical Center
🇺🇸Washington, District of Columbia, United States