Studying Biomarkers in Samples From Younger Patients With Kidney Cancer

Withdrawn

• Conditions: Congenital Mesoblastic Nephroma; Childhood Kidney Neoplasm; Rhabdoid Tumor of the Kidney; Clear Cell Renal Cell Carcinoma
• Interventions: Other: Laboratory Biomarker Analysis

• Registration Number: NCT01642095
• Lead Sponsor: Children's Oncology Group

Brief Summary

This laboratory study is looking into biomarkers in samples from younger patients with kidney cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat cancer.

Detailed Description

PRIMARY OBJECTIVES:

I. To determine whether focal adhesion kinase (FAK) is expressed and if FAK is phosphorylated in pediatric renal tumors.

OUTLINE:

Archived tumor tissue samples are analyzed for FAK expression by immunohistochemistry (IHC). IHC staining is compared in normal renal tissue, Wilms tumor (routine and anaplastic), malignant rhabdoid tumor of the kidney, clear cell sarcoma of the kidney, and mesoblastic nephroma.

Study Timeline

• Study First Submitted: 2012-07-15
• Study First Submitted QC: 2012-07-15
• Study First Posted: 2012-07-17
• Study Start: 2012-08-22
• Primary Completion: 2012-09-01
• Status Verified: 2017-10
• Last Update Submitted: 2018-08-03
• Last Update Posted: 2018-08-07

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Formalin-fixed, paraffin-embedded tissue samples from patients diagnosed with the following renal tumors:

  • Anaplastic Wilms tumor
  • Malignant rhabdoid tumor of the kidney
  • Clear cell sarcoma of the kidney
  • Mesoblastic nephroma

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Basic science (FAK expression)	Laboratory Biomarker Analysis	Archived tumor tissue samples are analyzed for FAK expression by IHC. IHC staining is compared in normal renal tissue, Wilms tumor (routine and anaplastic), malignant rhabdoid tumor of the kidney, clear cell sarcoma of the kidney, and mesoblastic nephroma.

Primary Outcome Measures

Name	Time	Method
FAK expression in pediatric renal tumors	Baseline

Trial Locations

Locations (1)

Childrens Oncology Group; 🇺🇸 Philadelphia, Pennsylvania, United States