Myocardial Dysfunction at Early Phase of Traumatic Brain Injury : Evaluation by Two Dimensional and Speckle Tracking Transthoracic Echocardiography
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- left ventricular ejection fraction
研究概览
简要总结
Traumatic brain injury (TBI) is a frequent pathology leading to major morbidity and mortality in young people. Cerebral flood flow maintenance is a major goal directed therapy to improve the prognosis of the patient. Due to cerebral-myocardial interaction, a myocardial dysfunction might occur at the early phase of the traumatic brain injury. This myocardial dysfunction could be partly responsible for a decrease in cerebral blood flow. In such case, improving myocardial dysfunction may help to increase cerebral blood flow and improve patient prognosis. In clinical practice the easiest and non invasive way to explore myocardial dysfunction is with transthoracic echocardiography. The objective of this trial is to investigate myocardial dysfunction at the early phase of traumatic brain injury, compared with a controlled group without TBI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •TBI patients
- •Inclusion Criteria:
- •Isolated and non opened traumatic brain injury
- •18 - 65 years old
- •Intubated and mechanically ventilated
- •Glasgow score < or = 9 or
- •Glasgow score between 9 and 13 (included) and Following Traumatic Coma Data Bank Tomographic Damages diffuse injuries type III or IV or mass lesion over 25ml and/or neurosurgical injuries
- •Medical insurance
排除标准
- •Treated major cardiovascular risks factors
- •cardiovascular past medical history (acute cardiovascular event)
- •Cardio thoracic surgery
- •Brain dead status
- •Inotrope drugs
- •Severe polytraumatism
- •Acute haemorrhage
- •Non echogenic patient
- •High level athlete
- •Incapacitated person by law and pregnant women
- •Discovery during echocardiography of underlying cardiomyopathy
- •Urgent neurosurgery required
- •Control patients
- •Inclusion Criteria:
- •Isolated and non opened traumatic brain injury
- •18 - 65 years old
- •Intubated and mechanically ventilated
- •Paired with TBI patient on age, BMI and sex
- •Undergoing urgent non severe surgery
- •Medical insurance
- •Exclusion Criteria:
- •Traumatic brain injury
- •Treated major cardiovascular risks factors
- •cardiovascular past medical history (acute cardiovascular event)
- •Cardio thoracic surgery
- •Inotrope and vasopressive drugs
- •Circulatory failure
- •Non echogenic patient
- •High level athlete
- •Incapacitated person by law and pregnant women
- •Discovery during echocardiography of underlying cardiomyopathy
- •Urgent neurosurgery required
研究组 & 干预措施
Traumatic brain injury
Two dimensional and speckle tracking transthoracic echocardiography in traumatic brain injured patients
- Glasgow score < or = 9 or
- Glasgow score between 9 and 13 (included) and Following Traumatic Coma Data Bank Tomographic Damages:
diffuse injuries type III or IV or mass lesion over 25ml and/or neurosurgical injuries
干预措施: Transthoracic echocardiography on TBI patients (Other)
Controls
Two dimensional and speckle tracking transthoracic echocardiography in control patients paired with traumatic brain injured patient on age, BMI and sex with the following criteria:
- Intubated and mechanically ventilated
- Undergoing urgent non severe surgery
干预措施: Transthoracic echocardiography on control patients (Other)
结局指标
主要结局
left ventricular ejection fraction
时间窗: within the first 24 hours after injury
次要结局
- Systolic strain rate by speckle tracking (in second)(within the first 24 hours after injury)
- Diastolic strain rate by speckle tracking (in second)(within the first 24 hours after injury)
- Systolic rotational velocity by speckle tracking (in degree by second)(within the first 24 hours after injury)
- Diastolic rotational velocity by speckle tracking (in degree by second)(within the first 24 hours after injury)
- Systolic twisting velocity by speckle tracking (in degree by second)(within the first 24 hours after injury)
- Diastolic untwisting velocity by speckle tracking (in degree by second)(within the first 24 hours after injury)
- Myocardial wall thickness (in millimeter)(within the first 24 hours after injury)
- left ventricular diastolic function (cm/sec)(within the first 24 hours after injury)
- Cardiac index(within the first 24 hours after injury)
- tissue doppler imaging (cm/sec)(within the first 24 hours after injury)
- right ventricular diastolic function(within the first 24 hours after injury)
- right ventricular systolic function(within the first 24 hours after injury)
- Strain evaluation by speckle tracking (in percentage of systolic duration)(within the first 24 hours after injury)