The impact of intra-operative haemofiltration during on-pump cardiac surgery on biomarkers of oxidative stress and healthcare outcomes of patients with impaired renal function: a pilot randomised trial

iverpool Heart and Chest Hospital NHS Trust (UK)0 sites199 target enrollmentStarted: July 15, 2009Last updated: December 10, 2019

Overview

2015 results in https://www.ncbi.nlm.nih.gov/pubmed/26119403 (added 04/11/2019) 2019 post-hoc analysis of biomarker levels in https://www.ncbi.nlm.nih.gov/pubmed/30987577 (added 04/11/2019)

•Current information as of 26/03/10:
•1\. Consenting men and women aged at least 18 years old
•2\. High\-risk patients elective for on\-pump valve replacement, coronary artery bypass graft surgery (CABG) or combined CABG and valve procedures
•3\. Patients with impaired renal function established preoperative by an estimated glomerular filtration rate (eGFR) \<50 ml/min
•Initial information at time of registration:
•1\. Male and female patients, at least 18 years old
•2\. Elective for on\-pump coronary artery bypass graft surgery (CABG)
•3\. Patients with impaired renal function established by pre\-operative estimated glomerular filtration rate (eGFR) less than 60 ml/min

•Current information as of 26/03/10:
•1\. Patients scheduled to undergoing cardiac surgery with anticipated CPB time \<60 minutes
•2\. Patients undergoing surgery on the great vessels (aortic surgery)
•3\. Patients with significant impaired liver function (serum bilirubin \> 60 or INR \>2 without anticoagulation)
•4\. Patients who are further down the line of renal failure (i.e. eGFR \<15 ml/min)
•5\. Patients on\-dialysis
•6\. Presence of malignancy
•7\. Pregnancy
•Initial information at time of registration:
•1\. Undergoing valve replacement surgery

Sponsor

iverpool Heart and Chest Hospital NHS Trust (UK)