The impact of intra-operative haemofiltration during on-pump cardiac surgery on biomarkers of oxidative stress and healthcare outcomes of patients with impaired renal function: a pilot randomised trial

iverpool Heart and Chest Hospital NHS Trust (UK)0 个研究点目标入组 199 人开始时间: 2009年7月15日最近更新: 2019年12月10日

适应症

试验速览

2015 results in https://www.ncbi.nlm.nih.gov/pubmed/26119403 (added 04/11/2019) 2019 post-hoc analysis of biomarker levels in https://www.ncbi.nlm.nih.gov/pubmed/30987577 (added 04/11/2019)

•Current information as of 26/03/10:
•1. Consenting men and women aged at least 18 years old
•2. High-risk patients elective for on-pump valve replacement, coronary artery bypass graft surgery (CABG) or combined CABG and valve procedures
•3. Patients with impaired renal function established preoperative by an estimated glomerular filtration rate (eGFR) <50 ml/min
•Initial information at time of registration:
•1. Male and female patients, at least 18 years old
•2. Elective for on-pump coronary artery bypass graft surgery (CABG)
•3. Patients with impaired renal function established by pre-operative estimated glomerular filtration rate (eGFR) less than 60 ml/min

•Current information as of 26/03/10:
•1. Patients scheduled to undergoing cardiac surgery with anticipated CPB time <60 minutes
•2. Patients undergoing surgery on the great vessels (aortic surgery)
•3. Patients with significant impaired liver function (serum bilirubin > 60 or INR >2 without anticoagulation)
•4. Patients who are further down the line of renal failure (i.e. eGFR <15 ml/min)
•5. Patients on-dialysis
•6. Presence of malignancy
•7. Pregnancy
•Initial information at time of registration:
•1. Undergoing valve replacement surgery
•2. Patients with significant impaired liver function (serum bilirubin greater than 60 or international normalised ratio [INR] greater than 2 without anticoagulation)
•3. Patients on-dialysis
•4. Patients that are pregnant or have malignancy

发起方

iverpool Heart and Chest Hospital NHS Trust (UK)