Role of Metabolic Tests in Infants presenting with Developmental Delay
Not Applicable
Completed
- Conditions
- Health Condition 1: E889- Metabolic disorder, unspecifiedHealth Condition 2: F88- Other disorders of psychological development
- Registration Number
- CTRI/2021/04/032521
- Lead Sponsor
- Dr Rochelle Natasha Gomes
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 53
Inclusion Criteria
1. Children aged 1 month to 1 year admitted in the Department of Paediatrics and presenting with GDD (global developmental delay with unclear etiology, progressive encephalopathy with seizures, hypotonia with or without poor feeding, failure to thrive, respiratory distress or vomiting).
2. Children with hypoglycaemic encephalopathy.
Exclusion Criteria
1. Children lesser than 1 month of age or older than 1 year at presentation.
2. Children with identified causes of GDD such as perinatal asphyxia/ hypoxic ischaemic encephalopathy stage 2 or 3, TORCH infections, post-meningitis sequelae, chromosomal disorder, hypothyroidism etc.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To establish the role of initial metabolic workup, Tandem Mass Spectrometry (TMS) and Gas Chromatography- Mass Spectrometry (GC-MS) in infants presenting with global developmental delay. <br/ ><br>Timepoint: 2 years
- Secondary Outcome Measures
Name Time Method To obtain the clinical profile of infants presenting with GDD requiring metabolic workup. <br/ ><br>Timepoint: 2 years