跳至主要内容
临床试验/NCT04067700
NCT04067700招募中不适用

Accuracy of Cardiopulmonary Exercise Testing in the Diagnosis of Myocardial Ischemia

Kuopio University Hospital2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2019年10月3日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
100
试验地点
2
主要终点
Presence of myocardial ischemia assessed by the cardiopulmanary exercise test

研究概览

简要总结

The investigators goal is to determine whether cardiopulmonary exercise testing (CPET) can be utilized in the diagnosis of myocardial ischemia. For the study participants the investigators will recruit patients who have been referred to myocardial perfusion PET/CT scan in Kuopio University Hospital. The participants will perform the CPET on a cycle ergometer on separate day after the perfusion scan. The investigators will compare the results of the PET/CT scan and CPET and evaluate if the possible perfusion defects detected in PET/CT correlate with the gas exchange parameters in CPET.

The patients who receive invasive coronary treatment (coronary bypass surgery or percutaneous coronary intervention) will be invited to perform additional CPET ja PET/CT tests six months after the treatment. The goal will be to determine whether the recovery of myocardial perfusion can be assessed with gas exchange parameters in CPET.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Referral to coronary perfusion PET/CT scan in Kuopio University Hospital

排除标准

  • Age under 18 years
  • Pregnancy or breastfeeding
  • Imprisonment
  • Care under forensic psychiatry

结局指标

主要结局

Presence of myocardial ischemia assessed by the cardiopulmanary exercise test

时间窗: 6 months

Criteria for myocardial ischemia that must be fulfilled are 1) Double sloping in the oxygen consumption/work rate trajectory, peak oxygen consumption below limit of the lowest normal, and abnormal oxygen pulse trajectory during the cardiopulmonary exercise test.

Presence of myocardial ischemia assessed by the myocardial perfusion positron emission tomography

时间窗: 6 months

Regional myocardial perfusion below 2.3 ml/g/min measured by the quantitative positron emission tomography is a marker of myocardial ischemia

次要结局

未报告次要终点

研究者

发起方
Kuopio University Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Tomi Laitinen

Professor, chief physician

Kuopio University Hospital

研究点 (2)

Loading locations...

相似试验