Accuracy of Cardiopulmonary Exercise Testing in the Diagnosis of Myocardial Ischemia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Presence of myocardial ischemia assessed by the cardiopulmanary exercise test
研究概览
简要总结
The investigators goal is to determine whether cardiopulmonary exercise testing (CPET) can be utilized in the diagnosis of myocardial ischemia. For the study participants the investigators will recruit patients who have been referred to myocardial perfusion PET/CT scan in Kuopio University Hospital. The participants will perform the CPET on a cycle ergometer on separate day after the perfusion scan. The investigators will compare the results of the PET/CT scan and CPET and evaluate if the possible perfusion defects detected in PET/CT correlate with the gas exchange parameters in CPET.
The patients who receive invasive coronary treatment (coronary bypass surgery or percutaneous coronary intervention) will be invited to perform additional CPET ja PET/CT tests six months after the treatment. The goal will be to determine whether the recovery of myocardial perfusion can be assessed with gas exchange parameters in CPET.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Referral to coronary perfusion PET/CT scan in Kuopio University Hospital
排除标准
- •Age under 18 years
- •Pregnancy or breastfeeding
- •Imprisonment
- •Care under forensic psychiatry
结局指标
主要结局
Presence of myocardial ischemia assessed by the cardiopulmanary exercise test
时间窗: 6 months
Criteria for myocardial ischemia that must be fulfilled are 1) Double sloping in the oxygen consumption/work rate trajectory, peak oxygen consumption below limit of the lowest normal, and abnormal oxygen pulse trajectory during the cardiopulmonary exercise test.
Presence of myocardial ischemia assessed by the myocardial perfusion positron emission tomography
时间窗: 6 months
Regional myocardial perfusion below 2.3 ml/g/min measured by the quantitative positron emission tomography is a marker of myocardial ischemia
次要结局
未报告次要终点
研究者
Tomi Laitinen
Professor, chief physician
Kuopio University Hospital
