PRP in 2ry Spontaneous Pneumothorax

Phase 1

• Conditions: Pneumothorax Spontaneous Secondary
• Interventions: Biological: Platelet Rich Plasma

• Registration Number: NCT03830645
• Lead Sponsor: Zagazig University

Brief Summary

secondary spontaneous pneumothorax patients will be enrolled ,all of them will receive PRP with different doses and schedules

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-05
• Study First Submitted: 2019-01-27
• Study First Submitted QC: 2019-02-01
• Study First Posted: 2019-02-05
• Status Verified: 2020-06
• Last Update Submitted: 2020-06-29
• Last Update Posted: 2020-06-30
• Primary Completion: 2020-11
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• COPD patients developed spontanous pneumothorax and was managed with intercostal tube insertion

Exclusion Criteria

• refusal of participation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Platelet rich plasma group	Platelet Rich Plasma	-

Primary Outcome Measures

Name	Time	Method
Air leak assessment by Cerfolio classification of the air leak by single observer	within 10 days after application of platelet rich plasma	Continuous:Air leak is Present throughout the respiratory cycle Inspiratory : Present during the inspiration phase of the respiratory cycle. Expiratory: Present only during the expiratory phase of the respiratory cycle Forced expiration: Present only when the patient coughs or forces exhalation
physician assessment of complete lung inflation by absence of signs of pneumothorax in chest x ray done to the patient during hospital stay	within 10 days after application of platelet rich plasma	no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation
recurrence of pneumothorax by physician interpretation of Chest x ray done to the patient in follow up visit i.e detecting jet balck translucency or border of collapsed lung	six months after removal of intercostal tube	no Chest x ray signs of pneumothorax i.e no jet balck translucency or border of collapsed lung) by physician interpretation

Trial Locations

Locations (1)

Zagazig University Faculty of medicine Chest Department; 🇪🇬 Zagazig, Asharqia, Egypt