Radiation Biodosimetry in Children Undergoing Total Body Irradiation
- Conditions
- Hematopoietic Stem Cell TransplantTotal-body Irradiation
- Registration Number
- NCT01337648
- Lead Sponsor
- Medical College of Wisconsin
- Brief Summary
The purpose of this study is to develop fecal tests that will determine the extent of radiation exposure in patients undergoing radiation treatment for cancer. This project will determine whether fecal biomarkers can be used to diagnose exposure to radiation.
- Detailed Description
Patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will have feces collected for use in the validation and refinement of new methods for rapid radiation biodosimetry. The stool samples will be collected before, and at defined times after TBI. Stool sampling will occur in the same manner that it does during routine patient care during HSCT.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 2
- All races are eligible
- 2 years to 21 years old
- Must be undergoing hematopoietic stem cell transplantation (either autologous or allogeneic) in conjunction with a conditioning regimen that includes total-body irradiation (TBI) (single or multiple fraction).
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To describe changes in gene expression associated with exposure to radiation prior to TBI treatment (baseline) and up to 2 weeks following the last dose of TBI Changes in gene expression will be measured as abundance of RNA levels relative to the weight of feces
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Children's Hospital of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States