Comparison between dexmedetomidine nebulization and dexamethasone nebulization in decreasing post intubation sore throat.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/09/036306
• Lead Sponsor: Kempegowda institute of medical sciences

Brief Summary

The study drug (dexamethasone 0.1mg/kg or dexmedetomidine 1 mcg/kg) will be delivered using a nebulization mask for 15 mins atoxygen source at 8L/min 10 min prior to induction. Post

nebulization vitalswill be recorded .GA will be induced with standard Anaesthesiaprotocol. Injection xylocard 1.5 mg/kg will be given 90 seconds prior to intubation.Intra-operative hemodynamic

monitoring will be done at 0 (post intubation),2,4,6,8,10 mins after intubation, thereafter every 5 mins intra operative period.Smooth extubation followed by monitoring every 15 mins in the PACU.



Assessment for the incidence and severity of sore throat, hoarseness ofvoice and cough will be carried out using a 4-point scale (0-3) at 0, 2, 4, 6,12, 24 hrs post extubation. IV Diclofenac 75 mg

will be given as rescue analgesic for severe sorethroat. Sedation will be monitored according to Ramsay Sedation score.



Any side effects such as dry mouth, post-operative nausea and vomiting(PONV), sedation, respiratory depression and hemodynamic instability will bemonitored and be treated accordingly.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-03-09
• Study Start: 2021-09-18

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I and II Age-18-70, both males and females Patients posted for elective surgeries under GA with endotracheal intubation, lasting < 2hrs duration.

Exclusion Criteria

• ASA III, IV Patients Patients with a history of upper respiratory tract infection, Asthma, sore throat.
• Anticipated difficult airway with Mallam Pati grade >2 Weight >80kgs, smokers.
• Surgeries requiring nasogastric tube insertion patients undergoing head and neck surgeries.
• Patients undergoing surgeries in prone position.
• pregnant and lactating women.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence and severity of post operative sore throat, hoarseness of voice and cough	assessed in the first 24 hours post operatively

Secondary Outcome Measures

Name	Time	Method
Hemodynamic changes and level of sedation	assessed in the first 24 hours post operative period

Trial Locations

Locations (1)

Kempegowda institute of medical sciences; 🇮🇳 Bangalore, KARNATAKA, India

Kempegowda institute of medical sciences

🇮🇳Bangalore, KARNATAKA, India

Dr Swathy S Iyengar

Principal investigator

9986356548

swathyiyengar85@gmail.com