A Longitudinal Observational Study of the Natural History and Management of Patients With HCC
- Conditions
- Hepatocellular Cancer
- Registration Number
- NCT02954094
- Lead Sponsor
- Target PharmaSolutions, Inc.
- Brief Summary
TARGET-HCC is a longitudinal, observational study of patients being managed for HCC in usual clinical practice. TARGET-HCC will create a research registry of participants with HCC within academic and community real-world practices in order to assess the safety and effectiveness of the entire spectrum of current and future therapies across diverse populations.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 10000
- Male or female patients, age ≥18 years
- Patients with a histological/cytological or radiological diagnosis of HCC (mixed HCC cholangiocarcinoma may be included; patients who are candidates for surgical and non-surgical treatment, as well as those being followed without specific HCC therapy may be included)
- Inability to provide written informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Establish a longitudinal observational cohort to understand the natural history and management of HCC, including the safety and outcomes of HCC treatment interventions utilized in usual clinical practice Up to 15 years
- Secondary Outcome Measures
Name Time Method Establish a Biorepository Specimen Bank (BSB) Up to 15 years Evaluate the impact of HCC treatment interventions and concomitant medications on comorbid conditions and liver function Up to 15 years Evaluate patient-reported outcomes measures during the natural course of HCC and management with HRQoL questionnaires Up to 15 years
Trial Locations
- Locations (72)
Baylor Scott & White All Saints
🇺🇸Fort Worth, Texas, United States
Research Specialists of Texas
🇺🇸Houston, Texas, United States
University of Arkansas
🇺🇸Little Rock, Arkansas, United States
Tampa General Medical Group
🇺🇸Tampa, Florida, United States
Piedmont Atlanta Hospital
🇺🇸Atlanta, Georgia, United States
Emory University Hospital
🇺🇸Atlanta, Georgia, United States
Johns Hopkins University
🇺🇸Baltimore, Maryland, United States
University of California-Davis
🇺🇸Sacramento, California, United States
University of Florida Hepatology Research at CTRB
🇺🇸Gainesville, Florida, United States
Schiff Center for Liver Diseases/University of Miami
🇺🇸Miami, Florida, United States
Gastro Florida
🇺🇸Clearwater, Florida, United States
Banner University Medical Center
🇺🇸Phoenix, Arizona, United States
University of California
🇺🇸San Francisco, California, United States
Georgetown University
🇺🇸Washington, District of Columbia, United States
University of Florida Health Gastroenterology
🇺🇸Jacksonville, Florida, United States
Piedmont Cancer Institute
🇺🇸Atlanta, Georgia, United States
Northwestern University Division of Gastroenterology and Hepatology
🇺🇸Chicago, Illinois, United States
University of Southern California/Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Stanford University
🇺🇸Palo Alto, California, United States
California Liver Research Institute
🇺🇸Pasadena, California, United States
Tulane University
🇺🇸New Orleans, Louisiana, United States
Mercy Medical Center, GI Research
🇺🇸Baltimore, Maryland, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Providence Health & Services Cancer Clinical Trials
🇺🇸Portland, Oregon, United States
Vanderbilt University Medical Center - GI Research Office
🇺🇸Nashville, Tennessee, United States
Clinical Research Institute@ Methodist Dallas Medical Center
🇺🇸Dallas, Texas, United States
University of Virginia
🇺🇸Charlottesville, Virginia, United States
Harborview Medical Center
🇺🇸Seattle, Washington, United States
Universitätsklinikum Aachen
🇩🇪Aachen, Germany
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
University of Chicago
🇺🇸Chicago, Illinois, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
Penn State Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Virginia Commonwealth University
🇺🇸Richmond, Virginia, United States
Wenatchee Valley Hospital & Clinics
🇺🇸Wenatchee, Washington, United States
Universitätsklinikum Frankfurt
🇩🇪Frankfurt, Germany
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
NYU Langone Health
🇺🇸New York, New York, United States
Weill Cornell Medical College
🇺🇸New York, New York, United States
Columbia University
🇺🇸New York, New York, United States
Bon Secours Liver Institute of Virginia
🇺🇸Richmond, Virginia, United States
University of Wisconsin
🇺🇸Madison, Wisconsin, United States
Hôpitaux Universitaires Paris Centre
🇫🇷Paris, France
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Southern Therapy and Advanced Research (STAR) LLC
🇺🇸Jackson, Mississippi, United States
Saint Louis University
🇺🇸Saint Louis, Missouri, United States
University of Nebraska Medical Center
🇺🇸Omaha, Nebraska, United States
Rutgers-Robert Wood Johnson Medical School
🇺🇸New Brunswick, New Jersey, United States
Northwell Health - Center for Liver Diseases
🇺🇸Manhasset, New York, United States
University of North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
Center for Liver Disease and Transplant at CMC
🇺🇸Charlotte, North Carolina, United States
University of Pennsylvania
🇺🇸Philadelphia, Pennsylvania, United States
CHU de Nice - Hôpital L'Archet 2
🇫🇷Nice, France
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Universitätsklinikum Düsseldorf
🇩🇪Düsseldorf, Germany
Universitätsklinikum Magdeburg
🇩🇪Magdeburg, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Universitätsklinikum Leipzig
🇩🇪Leipzig, Germany
Universitätsmedizin Mainz
🇩🇪Mainz, Germany
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
🇮🇹Milan, Italy
Humanitas Mirasole IRCCS
🇮🇹Rozzano, Italy
IRCCS "Casa Sollievo della Sofferenza"
🇮🇹San Giovanni Rotondo, Italy
Complejo Hospitalario Universitario A Coruña
🇪🇸Coruña, Spain
Hospital Puerta de Hierro Majadahonda
🇪🇸Madrid, Spain
Clínica Universidad de Navarra
🇪🇸Pamplona, Spain
A.O.U.P. di Palermo
🇮🇹Palermo, Italy
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Spain
Hospital Universitario Virgen del Rocío
🇪🇸Sevilla, Spain
Hospital Universitario Politècnic La Fe
🇪🇸Valencia, Spain