Correlation Between the Polymorphism ofβ2 AR and the Labor Progress After Labor Analgesia
- Conditions
- Labor Analgesia
- Interventions
- Genetic: β2AR polymorphism
- Registration Number
- NCT02708602
- Lead Sponsor
- Nanjing Maternity and Child Health Care Hospital
- Brief Summary
Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially the slow progress is one of the most important reasons for the occurrence of cesarean section during vaginal delivery, which still with a high incidence in recent years.Previous studies have found that there was a significant correlation between the genetic polymorphisms of β 2-adrenergic receptor (β2AR) and the duration of vaginal delivery.Therefore, the researchers intend to investigate the distribution of β2-adrenergic receptor (β2AR) genetic polymorphisms among Chinese parturient and observe the relationship between the genetic polymorphisms and labor process after labor analgesia.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 300
- Nulliparous women
- Required labor analgesia
- Chinese
- Spontaneous labor
- Contraindications for epidural analgesia
- Allergic to opioids and/or local anesthetics
- Failed to performing epidural catheterization
- Organic dysfunction
- Those who were not willing to or could not finish the whole study at any time
- Using or used in the past 14 days of the monoamine oxidase inhibitors
- Alcohol addictive or narcotic dependent patients
- Subjects with a nonvertex presentation or scheduled induction of labor
- Twin gestation and breech presentation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description β2AR Gln27Glu (CG group) β2AR polymorphism People with β2AR Gln27Glu genotype. β2AR Glu27Glu (GG group) β2AR polymorphism People with β2AR Glu27Glu genotype. β2AR Arg16Arg (AA group) β2AR polymorphism People with β2AR Arg16Arg genotype. β2AR Arg16Gly (AG group) β2AR polymorphism People with β2AR Arg16Gly genotype. β2AR Gly16Gly (GG group) β2AR polymorphism People with β2AR Gly16Gly genotype. β2AR Gln27Gln (CC group) β2AR polymorphism People with β2AR Gln16Gln genotype.
- Primary Outcome Measures
Name Time Method total labor process up to about 24h time from the regular uterus contractions until completed childbirth, assessed up to about 24h
duration of the first stage up to about 20h time from the regular uterus contractions to full cervix dilation,assessed up to about 20h
duration of the second stage up to about 2h time from full cervix dilation to the complete childbirth, assessed up to about 2h
Maternal visual analogue scale At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours)
- Secondary Outcome Measures
Name Time Method Neonatal weight At delivery At delivery
Use of oxytocin after analgesia At twenty-four hours postpartum At twenty-four hours postpartum
Neonatal Apgar scale At the first and fifth minutes after baby was born At the first and fifth minutes after baby was born
Maximal oxytocin dose At twenty-four hours postpartum At twenty-four hours postpartum
Maternal heart rate, respiratory rate, and blood pressure At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours) At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours)
method of delivery At time of placental delivery At time of placental delivery
Maternal modified Bromage scale At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours)
Rescue boluses, n of rescue boluses, and the consumption of the ropivacaine/sufentanil mixture At two hours postpartum At two hours postpartum
Maternal satisfaction with analgesia At two hours postpartum At two hours postpartum