Comparison of the excretion of flavonoids of orange juice by obese and non-obese

Phase 1

• Conditions: healthy; obesity; C18.654.726.500; HP1.007.091

• Registration Number: RBR-10xtk662
• Lead Sponsor: Faculdade de Ciências Farmacêuticas

Brief Summary

A large difference in the recovery of the urinary flavanone phase II metabolites was observed, with hesperetin-sulfate and hesperetin-sulfo-O-glucuronide being the major metabolites. Subjects were stratified according to their total excretion of flavanone metabolites as high, medium, and low excretors, but the expected correlation with the microbiome was not observed at the genus level. A second stratification was proposed according to phase II flavanone metabolism, whereby participants were divided into two excretion groups: Profiles A and B. Profile B individuals showed greater biotransformation of hesperetin-sulfate to hesperetin-sulfo-O-glucuronide, as well as transformation of flavanone-monoglucuronide to the respective diglucuronides, suggestive of an influence of polymorphisms on UDP-glucuronosyltransferase.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-02-03
• Study Start: 2021-09-08
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

No history of gastrointestinal, hepatic or renal disease;Do not be an alcoholic;Do not be diabetic;Do not be a vegetarian;Do not present any type of infection;Not be making use of vitamin and mineral supplements;Do not be a smoker;Do not practice intense physical activity;They can not be pregnant, breastfeeding or reporting hormone therapy for menopause

Exclusion Criteria

Be under 19 and over 40 years old;Do not be female;Have intestinal, kidney or liver disease;Being a vegetarian or a smoker;Practice intense physical activity;Being pregnant or breastfeeding

Study & Design

• Study Type: Intervention
• Study Design: Not specified