Intensity modulated radiation therapy in Patients with locally advanced inoperable gall bladder and pancreatic cancer

Phase 2

Active, not recruiting

• Conditions: Health Condition 1: null- Gall Bladder Cancer and Pancreatic Cancer

• Registration Number: CTRI/2016/08/007129
• Lead Sponsor: Tata Memorial Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Closed to Recruitment of Participants
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Inoperable locally advanced gall bladder and pancreatic cancer by virtue of vascular encasement of superior mesenteric artery (SMA), celiac artery, hepatic artery, portal vein (PV), SMV not amenable to resection for pancreatic cancers. Deep hilar invasion precluding R0 resection, vascular encasement or extensive duodenal infiltration for gall bladder cancers

Biopsy proven adenocarcinoma

KPS more than or equal to 70

Medically fit for chemotherapy

Normal hematological, renal and hepatic function (Serum Bilirubin <3mg/dl)

No prior history of treatment with radiation or chemotherapy

Patient willing and reliable for follow-up

Exclusion Criteria

Any other malignancy in any site

Expected survival < 3months

Severe co-morbid conditions ( Severe cardiac disorder, severe bronchial asthma, severely compromised liver function, psychological disorder)

Malignant ascitis

Distant metastases by clinical examination or by imaging/whole bodyPET scan

Study & Design

• Study Type: Interventional
• Study Design: Not specified