Regulation of exosome proteins in type 2 diabetes

Not Applicable

Conditions: Health Condition 1: E119- Type 2 diabetes mellitus without complications

Registration Number: CTRI/2020/12/029975

Lead Sponsor: Indian Council of Medical Research

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

Inclusion criteria - case

We will recruit consecutive subjects visiting Department of Medicine, TMA Pai Hospital, Udupi for routine check-up. People of both genders with age 45-55 years and are newly diagnosed with Type 2 Diabetes and are drug naïve are considered under this group. Fasting glucose more than 125mg/dL and post-prandial glucose of more than 200 mg/dL are considered type 2 diabetic as per ICMR guidelines.

Inclusion criteria - control

Age and gender matched individuals who will be visiting Department of Medicine, TMA Pai Hospital, Udupi and having levels of fasting glucose in the range of 80-110 mg/dL and post-prandial glucose in the range of 120-140 mg/dL are considered to be non-diabetic according to ICMR guidelines.

Exclusion Criteria

Exclusion criteria for case & control

Exclusion criteria includes subjects with hypertension, autoimmune diseases, infections or any other serious illness.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Knowledge of the molecular mechanisms underlying epigenetic changes in vasculature controlled by glucose and its modifications in diabetes may allow the design of novel therapeutic strategies to reduce the burden of vascular complications. Furthermore, altered exosome proteome signatures due to influence of epigenetic changes in vasculature detected early during the onset of diabetes in newly diagnosed subjects may prove useful as markers for vascular disease risk prediction.Timepoint: 3 Years

Secondary Outcome Measures