Changes in Sensitivity, Taste and Smell in Stroke Patients
- Conditions
- DysphagiaStroke
- Interventions
- Other: Sensitivity thresholdDiagnostic Test: FEES (flexible endoscopic evaluation of swallowing)Diagnostic Test: Taste-/smell-testDiagnostic Test: Neuropsychological testing
- Registration Number
- NCT03240965
- Lead Sponsor
- University of Giessen
- Brief Summary
This study evaluates changes in swallowing using endoscopic swallowing studies and measuring of pharyngeal sensitivity, taste and smell in stroke patients. Younger (\<60 years) and older (\>60 years) volunteers will serve as control.
- Detailed Description
Stroke is the second leading cause of death. At least 50% of stroke patients develop dysphagia, leading to aspiration pneumonia, which is the main cause of death in stroke \[2\].
It is assumed that normal sensitivity is vital for aspiration-free swallowing and for the triggering of the swallowing reflex.
Ali et al. demonstrated aspiration-free swallowing in healthy volunteers who underwent local anaesthesia of oral and pharyngeal structures \[1\]. Power et al. showed a reduced sensitivity of pharyngeal structures in stroke patients prone to aspiration \[3\].
By combining measuring sensitivity and flexible endoscopic swallowing studies, this study further investigates the role of sensitivity in swallowing Neuropsychological deficits of swallowing, such as swallowing apraxia or buccal hemineglect, is assessed by neuropsychological testing.
Additionally, there is no systematic research investigating the change in smell and taste in correlation with changes in stroke patients
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 200
Volunteers:
- informed consent
Stroke patients:
- informed consent
- new supratentorial stroke (<72 hours old) confirmed by CT (computed tomography) or MRI (magnetic resonance imaging)
- pre-existing stroke oder dysphagia
- extensive white matter lesions in CT- or MRI-scan
- allergies to odorous substances or flavoring
- contraindications for FEES (flexible endoscopic evaluation of swallowing), CT or MRI (stroke patients only)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Stroke patients Taste-/smell-test Stroke patients with supratentorial stroke, who are able to consent to participation in the study. Stroke patients Neuropsychological testing Stroke patients with supratentorial stroke, who are able to consent to participation in the study. Volunteers <60 years Taste-/smell-test Volunteers, who are able to consent to participation in the study, as control. Volunteers >60 years Sensitivity threshold Volunteers, who are able to consent to participation in the study, as control. Stroke patients Sensitivity threshold Stroke patients with supratentorial stroke, who are able to consent to participation in the study. Volunteers >60 years Taste-/smell-test Volunteers, who are able to consent to participation in the study, as control. Volunteers <60 years Sensitivity threshold Volunteers, who are able to consent to participation in the study, as control. Stroke patients FEES (flexible endoscopic evaluation of swallowing) Stroke patients with supratentorial stroke, who are able to consent to participation in the study.
- Primary Outcome Measures
Name Time Method Dysphagia 96 hours after initial symptoms Changes found in endoscopic swallowing study :
Presence and severity of dysphagia (measured with Rosenbek's Penetration/Aspiration-scale)
- Secondary Outcome Measures
Name Time Method Neuropsychological deficits 96 hours after initial symptoms Agnosia, neglect
Lesion site 96 hours after initial symptoms Side, vascular territory, swallowing relevant structures
Taste/Smell 96 hours after initial symptoms Smell-/Taste-score
Sensitivity 96 hours after initial symptoms Sensitivity of faucial pillar region
Trial Locations
- Locations (1)
Universitätsklinikum Gießen
🇩🇪Gießen, Hessen, Germany