Munich Diabetes Family Study

Conditions: TYP-2-DIABETES
E11.9

Registration Number: DRKS00004229

Lead Sponsor: Else Kröner-fresenius-Zentrum für ErnährungsmedizinKlinikum rechts der Isar der TU MünchenUptown München Campus D

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting stopped after recruiting started

Sex: All

Target Recruitment: 24

Inclusion Criteria

type 2 diabetes families: at least two generations (parents, children); at least one parent with T2D; at least three participants per family (trio”) with one disease-free index subject
- Caucasian origin
- no BMI restriction
- written informed consent

Exclusion Criteria

- severe diseases, e.g. cancer, COPD, severe heart disease, progressive renal failure, severe psychiatric or neurological diseases
- type 1 diabetes, MODY or other rare types of diabetes
- drug or alcohol abuse
- continuous treatment with drugs influencing glucose tolerance, insulin sensitivity and/or insulin secretion
- continuous treatment with oral anticoagulants or antithrombotics (except ASS 100)
- gastrointestinal diseases impairing glucose absorption during oGTT
- insufficient language skills
- lack of written informed consent

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterization (geno-/phenotyping) of a cohort of families with type 2 diabetes.

Secondary Outcome Measures

Name	Time	Method
- identification of potential new diagnostic biomarkers in a T2D risk cohort<br>- validation and cross-validation of newly detected biomarker signatures <br>- function of diabetes-related single nucleotid polymorphisms <br>- development and validation of specific dietary recommendations for disease prevention