POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

Completed

• Conditions: 1. Postoperative Cognitive Dysfunction
• Interventions: Other: The intervention will be Mini-Mental Status Examination (MMSE)

• Registration Number: NCT01199913
• Lead Sponsor: Loma Linda University

Brief Summary

The use of desflurane in elderly subjects (\>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Study First Submitted: 2010-09-09
• Study First Submitted QC: 2010-09-09
• Study First Posted: 2010-09-13
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-08
• Last Update Posted: 2014-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• Adult patients (>65 years old)
• Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
• Airway management expected to include endotracheal intubation
• Expected surgical duration 120 to 240 minutes

Exclusion Criteria

• Pre-existing significant psychiatric disease or mental status changes

• Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease

• Patient's weighing >50% ideal body weight

  • Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
  • Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet

• Patients who have undergone a general anesthetic within the past 7 days

• Patient refusal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
desflurane and sevoflurane	The intervention will be Mini-Mental Status Examination (MMSE)	Subjects will be randomized to either desflurane or sevoflurane. They will be given the Mini Mental State exam at 1, 6 and 24 hours after the end of anesthesia.

Primary Outcome Measures

Name	Time	Method
POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia	Both groups will complete the MMSE at 1, 6, and 24 hours after the end of anesthesia or to disharge up to 7 days.	The primary outcome measure will be changes in cognitive function after anesthesia as measured by MMSE.

Secondary Outcome Measures

Name	Time	Method
Secondary outcome measures will include: 1) time to extubation, anesthetic complications (e.g. coughing during extubation), 2) time to readiness for discharge from PACU, 3) length of hospital stay, and 4) any postoperative complications.	24 hours to 7 days

Trial Locations

Locations (1)

Loma Linda University; 🇺🇸 Loma Linda, California, United States