NCT01199913已完成不适用
Incidence of Postoperative Cognitive Dysfunction in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia: A Randomized, Controlled Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia
研究概览
简要总结
The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (>65 years old)
- •Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
- •Airway management expected to include endotracheal intubation
- •Expected surgical duration 120 to 240 minutes
排除标准
- •Pre-existing significant psychiatric disease or mental status changes
- •Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease
- •Patient's weighing >50% ideal body weight
- •Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
- •Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet
- •Patients who have undergone a general anesthetic within the past 7 days
- •Patient refusal
结局指标
主要结局
POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia
时间窗: Both groups will complete the MMSE at 1, 6, and 24 hours after the end of anesthesia or to disharge up to 7 days.
The primary outcome measure will be changes in cognitive function after anesthesia as measured by MMSE.
次要结局
- Secondary outcome measures will include: 1) time to extubation, anesthetic complications (e.g. coughing during extubation), 2) time to readiness for discharge from PACU, 3) length of hospital stay, and 4) any postoperative complications.(24 hours to 7 days)
研究者
Richard Applegate
MD
Loma Linda University
研究点 (1)
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