The research on the mechanism of 'liver-soothing with blood-nourishing and detoxifying' therapy in the treatment of psoriasis patients with depressive state based on inflammation pathway mediated by HPA-MC

Beijing Hospital of Traditional Chinese Medicine0 个研究点开始时间: 待定最近更新: 2023年2月20日

适应症

试验速览

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•1. Meet the diagnostic criteria for psoriasis vulgaris, and all are in the stationary phase;
•2. Meet the syndrome differentiation criteria of Psoriasis Vulgaris with Blood Dryness and Liver-Stagnation Syndrome (All the selected patients have been determined by at least two associate chief physicians or experts with titles above to determine whether they belong to the Blood Dryness and Liver-Stagnation Syndrome);
•3. Adopt the DSM-IV axis I mental disorder clinical interview (non-patient version) to exclude any disease or disorder in the DSM-IV diagnostic criteria, and no mental disorder in the first-degree relatives;
•4. Hamilton Depression Scale (HAMD) score >= 7 points, and Hamilton Anxiety Scale (HAMA) score < 7 points;
•5. Age range 18-60 years old;
•6. Volunteer to participate in this study and sign an informed consent form.

•1. Patients who have received immunomodulators or hormones systematically in the past month;
•2. Pregnant and lactating women;
•3. Brain organic diseases or clear physical diseases;
•4. History of head trauma, loss of consciousness for more than 1 hour; or obvious mental retardation;
•5. Patients with a clear history of schizophrenia and history of alcohol and drug abuse or dependence;
•6. Patients with severe depression, HAMD scale score >= 35 points;
•7. There are metal foreign bodies in the body (such as metal dentures, pacemakers, etc.) that affect the magnetic resonance examination;
•8. Patients with severe heart, lung, liver, kidney, digestive tract and other visceral diseases.

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