Vessel-sparing Technique Versus Conventional Repair of PFUI: A Prospective Comparative Study
- Conditions
- Traumatic Urethral Stricture, Male, Overlapping Sites
- Interventions
- Procedure: uretheroplasty
- Registration Number
- NCT06248047
- Lead Sponsor
- Assiut University
- Brief Summary
Pelvic fracture is associated with urethral injury in about 10% of patients . The common site of injury is at the bulbomembranous Junction and anastomotic urethroplasty with a tension free anastomosis remains the gold standard management for pelvic fracture urethral injury (PFUI) .
Traditional reconstruction of PFUI requires mobilization of the bulbar urethra to reach the prostatic apex with deep dissection of the spongiosum and detachment of the bulb from the perineal membrane at the site of the bulbomembranous urethral injury, a maneuver that requires division of the bulbar arteries . Then, the distal bulb and bulbar urethra will depend on retrograde blood flow through the glans and some perforating branches of the dorsal penile artery and this is usually sufficient to maintain good vitality of the spongiosum and urethra under normal circumstances .
When the distal blood supply to the urethra is compromised, either by congenital anomalies such a hypospadias, by previous surgery, or by the pre-existing pelvic fracture, the retrograde flow to the spongiosum is insufficient . In such cases, traditional anastomotic urethroplasty may result in ischemic bulbar necrosis, leading to a reconstructive failure and these patients usually fail to void soon after removal of the catheter, with subsequent retrograde urethrogram (RUG) showing a long bulbar urethral defect .
In 2007, Jordan et al described a modification to excision and primary anastomosis (EPA) in the proximal bulbar urethral strictures particularly post radical prostatectomy, which includes mobilizing and preserving the bulbar arteries with the continuity of the corpus spongiosum is maintained .
Gomez et al believed that vessel-sparing anastomotic urethroplasty is highly relevant in the PFUI scenario as it can theoretically help to avoid ischemic failure and cold glans syndrome improving sexual arousal. Consequently, they modified the standard reconstructive technique for PFUI by preserving bulbar arterial inflow .
So that, we decide to compare between vessel-sparing technique and conventional repair in management of PFUI through a prospective study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Male
- Target Recruitment
- 32
- Adult male patients ≥ 18 years old with PFUI
- Recurrent cases. • History of concomitant bladder neck injury
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description the new technique uretheroplasty the patients will undergo repair with sparing of the vessels .then follow up by uroflow ,ascending urethrogram and penile doppler . conventional repair uretheroplasty the patients will undergo repair with no regard to the vessels .then follow up by uroflow ,ascending urethrogram and penile doppler .
- Primary Outcome Measures
Name Time Method Retrograde Urethrogram RUG three months after the operation contrast study to evaluate and delineate the urethera
UROFLOWMETERY three months after the operation the speed and feasibility of micturition measured by non invasive pressure flow study Q max more than 10ml/sec
postmicturition residue three months after the operation abdominal ultrasound done to evaluate PMR
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Assiut University
🇪🇬Assiut, Egypt