Assessment of Body Composition and Physical Function

Completed

Interventions: Other: Body Composition Assessment
Other: Modified Physical Performance Test
Other: Hand grip strength
Other: 6-minute walk test
Procedure: Measurement of blood glucose and insulin

Brief Summary: Sarcopenia, which is the loss of muscle mass and strength or physical function, naturally occurs in aging. In sarcopenic obesity, growth of muscle mass and increments in strength do not parallel weight gain, and places older adults at increased risk of falls, fractures, physical disability, frailty, and mortality from too low muscle strength relative to body size. The goal of the study is to assess body composition and physical function in older adults with obesity.

Detailed Description: This is a cross-sectional study in 40 adults aged 60 to 80 years with obesity. Body composition, physical function, and insulin resistance will be measured. Subjects who satisfy the eligibility criteria and sign the informed consent will be enrolled. Subjects will complete an assessment of body composition by bioelectrical impedance analysis and tests of physical performance. Blood will be drawn for measurement of fasting glucose and insulin.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

self-reported history of diabetes, or cancer or significant cardiovascular or hepatic or renal disease or dysfunction.
clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, or celiac disease.

Arm && Interventions

Group	Intervention	Description
Older Adults	Modified Physical Performance Test	Adults 60-80 years of age with body mass index \> 30kg/m2
Older Adults	Measurement of blood glucose and insulin	Adults 60-80 years of age with body mass index \> 30kg/m2
Older Adults	Body Composition Assessment	Adults 60-80 years of age with body mass index \> 30kg/m2
Older Adults	Hand grip strength	Adults 60-80 years of age with body mass index \> 30kg/m2
Older Adults	6-minute walk test	Adults 60-80 years of age with body mass index \> 30kg/m2

Primary Outcome Measures

Name	Time	Method
Fat Mass	One day	Measurement of fat mass
Fat-free Mass	One day	Measurement of fat-free mass
Modified Physical Performance Test	One day	Test for assessing physical performance. The scale ranges from 0 to 36 and higher score indicates a better outcome

Secondary Outcome Measures

Name	Time	Method
6-minute Walk Test	One day	Test of walking capacity assessed as distance covered in 6 minutes
Homeostasis Model Assessment of Insulin Resistance (HOMA-IR)	One day	Assessment of insulin resistance from blood glucose and insulin. HOMA-IR was calculated as: fasting insulin (μU/mL) × fasting glucose (mmol/L)\]/22.5 Higher scores indicate greater insulin resistance and a worse outcome. There is no theoretical minimum and/or maximum value for HOMA-IR. Studies have suggested a variety of values that vary based on factors such as gender and age. For example, a large epidemiologic study found that HOMA-IR score of 1.85 in women and 2.17 in men indicated insulin resistance. In another study, the HOMA-IR cut point was found to be 2.37 and 2.38 in 70-year old men and women respectively (see references).
Hand Grip Strength	One day	Assessment of grip strength using a hand dynamometer