Investigation of immune responses against Staphylococcus aureus * analysis of antibodies and antibody producing cells in patients with Staphylococcus aureus infections and patients whose wounds are colonised by Staphylococcus aureus

Completed

Conditions: hospital infections
S. aureus colonization and infection
10004018
10040785

Registration Number: NL-OMON33490

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

Provision of written informed consent and history of S. aureus infection, presence of toxin producing strains or wound colonisation

Exclusion Criteria

1. A history of, or presence of diseases or other conditions in which no blood donation can take place (as judged by the investigator or the treating physician).
2.Evidence of having serum hepatitis or carrying the hepatitis B surface antigen or Hepatitis C antibodies or being HIV positive.
3. Abuse of alcohol or drugs or any other condition.
4. Pregnancy.
5. Positive drug screen for Benzodiazepines, methadone, metamphetamine, morphine, PCP, tricyclic antidepressants, amphetamines, cocaine, cannabinoids, barbiturates and ethanol
6. Subjects, who in the opinion of the investigator or the treating physician should not, for reasons of safety, participate in the study.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study parameter is a detectable IgA or IgG response against<br /><br>staphylococcal antigens relevant for the development of therapeutic antibodies.<br /><br>The endpoint will be defined by the absence of a detectable IgA or IgG response<br /><br>against antigens relevant for the development of therapeutic antibodies.</p><br>

Secondary Outcome Measures