Diagnosis of periodontal disease using genetic marker in saliva
- Conditions
- Diseases of the musculo-skeletal system and connective tissue
- Registration Number
- KCT0001024
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 18
A. Advanced Periodontal Disease
- Patients with chronic advaced periodontitis
- Patients required primary treatment of periodontal scaling, subgingival curettage, and agreed with the basic periodontal therapy based on the standard protocol
- subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing
B. Mild Periodontal Disease
- Patients with chronic initial periodontitis
- Patients required primary treatment of periodontal scaling, subgingival curettage, and agreed with the basic periodontal therapy based on the standard protocol
- subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing
C. Control
- Healthy periodontal patients ( more than 20 permanent teeth are present , in all parts of deep periodontal pockets measuring 4mm or less, and height is 2mm or less clinical attachment person)
- subjects agreed collecting saliva and gingival crevicular fluid and physicochemical tests and genetic testing
- Received periodontal treatment within the last six months
- recently taken antibiotics within 3 months if you need a prescription antibiotic prophylaxis
- taking the drug can affect periodontal status for a long period of time
- pregnant or breastfeeding
- In case of oral inflammatory mucosal disease (Lichen planus, etc.)
- Patients with a history of alcoholism or drug abuse
- other special systemic disease (high blood pressure)
- ages under 18
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method espression of MicroRNA
- Secondary Outcome Measures
Name Time Method cytokine analysis