Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction
- Conditions
- Myocardial InfarctionReperfusion Injury
- Registration Number
- NCT01414452
- Lead Sponsor
- Universiteit Antwerpen
- Brief Summary
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 250
- STEMI treated with primary PCI
- ischemia time >12h
- use of immunosuppressive therapy
- unsuccessful recanalisation
- not-interpretable ST-T segment
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method occurrence of reperfusion injury after succesfull primary PCI within 90 min after PCI Serial ECG measurements (before and after PCI to assess extent of ST segment resolution as marker of reperfusion injury
- Secondary Outcome Measures
Name Time Method Major cardiovascular event rate at 1 year combined endpoint of hospitalisation (or extension of hospitalisation) for heart failure and cardiac death in a period of one year
Trial Locations
- Locations (1)
University hospital
🇧🇪Edegem, Antwerp, Belgium