The Effect of Infliximab on Sperm Quality

• Conditions: Crohn's Disease; Ulcerative Colitis
• Interventions: Other: sperm quality test

• Registration Number: NCT00745329
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

Background: The treatment of inflammatory bowel diseases (IBD) is based mainly on 3 compounds: 1- 5 aminosalysilates . 2- immunomodulators (Azathioprines). 3- Biologic therapies (Infliximab, Adalimumab) . There are no established data in the literature whether these therapies effects sperm quality. Given that a large number of the patients are young men in the reproductive stage of their lives , It of importance to investigate these effect.

Aim: To investigate the effect of chronic treatment of any of the three therapy mentioned above, on sperm quality .

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-09
• Study First Submitted: 2008-09-01
• Study First Submitted QC: 2008-09-02
• Last Update Submitted: 2008-09-02
• Study First Posted: 2008-09-03
• Last Update Posted: 2008-09-03
• Study Start: 2008-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 100

Inclusion Criteria

• Male above the age of 18
• Capable of giving informed consent
• Diagnosed with IBD at least 3 months
• Patients that are going to start a treatment with on of the following groups: 5ASA, Azathioprines, infliximab or ADAlimumab
• Patients that are treated with therapies mentioned in article 4 for at least 3 months

Exclusion Criteria

• Male younger than 18

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
2	sperm quality test	1. patients 2. healthy volunteers