Monitoring of Cerebral Autoregulation in Pediatric ECMO (ECMOX 1)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Extracorporeal Membrane Oxygenation Complication
- Sponsor
- Nantes University Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Feasibility of continuous cerebral autoregulation monitoring
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Children supported by Extra-Corporeal Membrane Oxygenation (ECMO) present a high risk of neurological complications and cerebral autoregulation (CA) impairment may be a risk factor. Our first objective is to investigate the feasibility of CA continuous monitoring during ECMO treatment. The second objective is to analyze the relationship between CA impairment and neurological outcome.
Detailed Description
Patients : All children treated by ECMO in the PICU of the Universitary hospital of Nantes, France and of IRCCS Giannina Gaslini Institute, Genoa, Italy Measurements: A correlation coefficient between the variations of regional cerebral oxygen saturation (rScO2) as a surrogate of cerebral blood flow and the variations of arterial blood pressure (ABP) is calculated as an index of autoregulation (cerebral oxygenation index (COx), ICM+ software®). CA is monitored either on left (COxl) or both sides. A COx \> 0.3 is considered as critical. Neurological outcome is assessed by the onset of an acute neurologic event (ANE) during the ECMO run.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients 18 years treated by ECMO
Exclusion Criteria
- •Lack of parental consent
Outcomes
Primary Outcomes
Feasibility of continuous cerebral autoregulation monitoring
Time Frame: 12 hours after Extra-Corporeal Membrane Oxygenation
Percentage of time when cerebral autoregulation metrics are available. cerebral autoregulation metrics variations under Extra-Corporeal Membrane Oxygenation
Secondary Outcomes
- Correlation between cerebral autoregulation metrics and neurological outcome(12 hours after Extra-Corporeal Membrane Oxygenation)