Standing Cognition and Co-morbidities of POTS Evaluation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 139
- Locations
- 1
- Primary Endpoint
- Executive Function (Stroop Word-color Test)
Study Overview
Brief Summary
The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 13 Years to 60 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Previously diagnosed with POTS, or healthy control
- •Age between 13-60 years
- •Participants may be any race, ethnicity, sex, or gender
- •Able and willing to provide informed consent
Exclusion Criteria
- •Inability to give, or withdrawal of, informed consent
- •Age ≤ 13 or ≥ 61 years
- •Prisoners
- •Unable to stand
Arms & Interventions
Standing
Participants will complete cognitive testing while standing.
Intervention: Standing (Behavioral)
Supine
Participants will complete cognitive testing while supine.
Intervention: Supine (Behavioral)
Outcomes
Primary Outcomes
Executive Function (Stroop Word-color Test)
Time Frame: 1 hour
Testing scores are normalized using T-scores for predicted values based on age and education for each participant. Scores range from 0 to 100. Higher numbers indicate better cognition. Testing will be performed while participants are supine and standing.
Secondary Outcomes
- Attention Score Using Cogstate Identification Task(1 hour)
- Number of Participants With Hypermobile Ehlers-Danlos Syndrome (hEDS)(1 hour)
- Heart Rate Standing Minus Heart Rate Supine(1 hour)
Investigators
Amanda Miller
Postdoctoral Fellow
Milton S. Hershey Medical Center