Clinical and Economic Impact of an Electronic Medical Record Interfaced Decision Support System Reinforced With Patient Specific Pharmacogenetic Data for Minimizing Severe Drug-Drug Interactions

Not Applicable

Completed

• Conditions: Healthcare
• Interventions: Other: DDI+ System and Pharmacogenetic Data

• Registration Number: NCT01765621
• Lead Sponsor: Leumit Health Services

Brief Summary

Leumit Health Services, an health maintenance organization operating in Israel, will incorporate a web-based, decision support system for handling drug-drug interactions and drug information, termed DDI+ reinforced with patient specific pharmacogenetic data. The investigators hypothesize that implementing such a system will reduce health-care expenditures (e.g., hospital admissions, referrals to ERs, Imaging procedures).

Detailed Description

Not available

Study Timeline

• Study Start: 2013-01
• Study First Submitted: 2013-01-09
• Study First Submitted QC: 2013-01-09
• Study First Posted: 2013-01-10
• Status Verified: 2014-10
• Primary Completion: 2014-10
• Study Completion: 2014-10
• Last Update Submitted: 2014-10-20
• Last Update Posted: 2014-10-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 973

Inclusion Criteria

• Number of chronic concomitant drugs ≥5
• treated with 1 or more drugs with a well established interaction with 1 or more of the following CYP450 enzymes: 2c9, 2c19, 2d6

Exclusion Criteria

• Patients diagnosed with HIV/AIDS, and/or viral hepatitis B or C

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
DDI+ and Pharmacogenetic data	DDI+ System and Pharmacogenetic Data	DDI+ System and Pharmacogenetic data

Primary Outcome Measures

Name	Time	Method
Hospital Admissions	up to 12 month post initiation

Trial Locations

Locations (1)

Leumit Health Services; 🇮🇱 Tel-Aviv, Israel