Randomized Evaluation of Patients With Stable Angina Comparing Diagnostic Examinations.
Recruiting
- Conditions
- Chest PainStable Angina Pectoris, CCS Class I to IIIAngina EquivalentCoronary Artery Disease
- Registration Number
- NL-OMON25114
- Lead Sponsor
- American College of Radiology Imaging Network
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 4300
Inclusion Criteria
1. Willing and able to provide a written informed consent;
2. 40 years or older;
Exclusion Criteria
1. Prior revascularization;
2. Not suitable to undergo CT with an iodinated contrast agent;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare outcomes of participants with symptoms of stable angina or angina equivalent evaluated with an anatomic imaging strategy using CCTA as initial method of CAD diagnosis (Group A) to a combined functional and anatomic imaging strategy of SPECT MPI/ICA (Group B) as a guide to OMT.
- Secondary Outcome Measures
Name Time Method 1. To evaluate the ability of available prognostic indices to predict revascularization or MACE using CCTA information and to develop new indices using the RESCUE trial data;<br /><br>2. To determine the cost, effectiveness, and incremental cost-effectiveness of CCTA versus SPECT MPI/ICA in the evaluation of participants with symptoms of stable angina;<br /><br>3. To compare angina symptoms and self-reported health status of participants with symptoms of stable angina undergoing CCTA as initial method of CAD diagnosis to SPECT MPI/ICA as a guide to OMT.