NCT03462277已完成不适用
DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease
Chongqing Medical University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2018年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- DNA Methylation and Hydroxymethylation Levels
研究概览
简要总结
The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.
详细描述
- To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease.
- To investigate the relationship between DNA methylation and hydroxymethylation and the degree of coronary atherosclerosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.
排除标准
- •Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.
结局指标
主要结局
DNA Methylation and Hydroxymethylation Levels
时间窗: 1 month
Collection of blood samples and measuring the samples by PCR and ELISA
次要结局
未报告次要终点
研究者
Dongying Zhang
doctor
Chongqing Medical University
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Epigenetics, DNA Methylation Patterns and Periodontal DiseasePeriodontal DiseaseNCT01399034University of North Carolina, Chapel Hill98
Unknown
不适用
DNA Methylation for Screening Uterine Cervical Lesions: A Case-control StudyDNA MethylationUterine Cervical CancerHigh Grade Squamous Intraepithelial LesionsLow Grade Squamous Intraepithelial LesionsNCT03961191Lei Li300
Unknown
不适用
DNA Promoter Hypermethylation as a Blood Based Maker for Pancreatic CancerPancreatic DiseasesPancreatic NeoplasmsPancreatitisNCT02079363Aalborg University Hospital330
已完成
不适用
Validation of DNA Methylation Biomarkers for Oral Cancer DetectionRecurrenceOral CancerNCT02648789Taipei Veterans General Hospital, Taiwan46
已完成
不适用
Investigation of correlation between DNA methylation in hepatic derived cells and CYP3A4 actibity in healthy volunteershealthy male and femaleJPRN-jRCTs071190031Yoshihara Tatsuya20