NCT00442585已完成1 期
Double Blind, Randomised, Parallel Group, Placebo Controlled Clinical Trial of S(+)-Ibuprofen Effects on TxB2 Concentrations and Platelet Aggregation in Aspirin-treated Healthy Adult Volunteers
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 72
- 试验地点
- 2
- 主要终点
- Percentage of inhibition of TxB2 after 1, 3, 7 and 10 days
研究概览
简要总结
The purpose of this clinical trial is to determine whether S(+)-ibuprofen affect the platelet inhibition under steady state acetylsalicylic acid conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy caucasian volunteer
- •Must be able to swallow tablets
排除标准
- •Underlying diseases
- •Ulcus pepticum in history
- •Abuse of alcoholic beverages (40g/d)
- •Hypersensitivity to investigational medicinal products
结局指标
主要结局
Percentage of inhibition of TxB2 after 1, 3, 7 and 10 days
次要结局
- percentage of subjects with >90% inhibition of TxB2, CEPI-CT and CADP-CT measured by PAF100,
- prostacyclin metabolite
研究者
研究点 (2)
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