Cohort Study on Treatment Comes of Catheter-based Therapy in Patients With Acute Pulmonary Embolism in Hong Kong - the HONG KONG PECT Registry
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Inpatient mortality rates
研究概览
简要总结
This retrospective cohort study (Hong Kong PECT Registry) compares treatment outcomes between different percutaneous catheter-based therapies in patients with acute pulmonary embolism (PE). PE is a critical condition with potential for rapid deterioration and mortality before treatment. While availability of catheter-based therapy contributed to the declining mortality rates of PE, selecting the appropriate intervention remains key. There are primarily two modes of therapies available: Catheter-directed thrombolysis and Aspiration thrombectomy (e.g., Penumbra, Flowtriever, AlphaVac) Given limited direct comparisons between these methods, the study will evaluate their efficacy, safety, and clinical outcomes of these treatment strategies in acute PE patients.
详细描述
Introduction Acute pulmonary embolism is a well known disease to all cardiologists and physicians. Not only because of the disease is not uncommon, not a small portion of patients suffered from acute pulmonary embolism may deteriorate suddenly and rapidly, before the intiation of treatment. Luckily, time trend analyses throughout the world the mortality of pulmonary embolism is on decreasing trend.
Besides traditional systemic thrombolysis and surgical embolectomy, percutaneous catheter directed treatment has been used recently as well, especially those who are poor surgical candidates while not eligible to systemic thrombolytics. There are different types of percutaneous catheter directed treatment. Boardly can be divided as the catheter interventions with or without use of thrombolysis and catheter based aspiration thrombectomy. In our local experiences, EKOS is one of the example as catheter interventions with the use of thrombolysis, by using ultrasound assisstance. While IndigoVR Mechanical Thrombectomy System (Penumbra), Flowtriever system (Inari) and AlphaVac (angiodynamic) are some of examples of the aspiration thrombectomy.
Direct comparions between different types of percutaneous cathter directed treatment is limited. With the local datas avaliable, we would like to compare the efficacy, safety and other significant clinical outcomes between different types of catheter-based therapies.
Objectives In patient with pulmonary embolism who underwent percutaneous catheter directed treatment , is there any difference interms of clinical efficacy, safety outcomes and other significant clinlcal parameters? Patients and Methods Inclusion criteria
- Adults >= 18 years
- Patients who were admitted to Pok Oi Hospital, Tuen Mun Hospital, Prince of Wales Hopstial from Jan 2016 to December 2021 and diagnosed to have acute pulmonary embolism
- Receiveed treatment of any types of catheter-based therapy for pulmonary embolism Exclusion Criteria
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who is admitted with a diagnosis of acute pulmonary embolism
- •Patient who receives any types of catheter-based therapy for acute pulmonary embolism.
排除标准
- •nil. This is a all-comer registry.
结局指标
主要结局
Inpatient mortality rates
时间窗: baseline, through hospital stay, an average of 7 days
death of a patient occurring during the index hospitalization of pulmonary embolism.
次要结局
- procedural related complications(baseline, 72 hours post operation)
- major bleeding (as defined by BARC)(baseline, 72 hours post operation)
- hemoglobin change within 72 hours of the procedure(baseline, 72 hours post operation)
- change in the right ventricle to left ventricle ratio(baseline, 72 hours post operation)
- mean pulmonary artery pressure(baseline, 72 hours post operation)
- clinical deterioration and/or escalation to a bailout therapy(baseline, 72 hours post operation)
- PE related mortality in 90 days(baseline, 90 days)
研究者
GuangMing Tan
Assistant Professor
Chinese University of Hong Kong