GnRH Anonist as Luteal Support in Frozen-thawed Embryo Transfer Cycles
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 100
- 主要终点
- Implantation rate
研究概览
简要总结
Back ground: A single dose of GnRH analogue in the luteal phase is reported to improve the outcome of IVF/ICSI treatments but the effect in FET cycles has not been reported.
Aim: To compare the results of frozen thawed embryo transfers with and without GnRHa analogue support Primary end point: IR, PR, on going PR Secondary end point: hCH, E2 and progesterone levels 14 days after thawing
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •20 - 45 year old women comig to frozen thawed embryo transfer
排除标准
- •The age of the woman over 42 years during the initial ICF/ICSI- treatment from which the embryos derive
- •Abnormal uterus
- •Known abnormality of karyotype of the woman or her partner
- •Severe male factor as an exclusive reason for subfertility
- •Allegy for triptorelin acetate
研究组 & 干预措施
Hormone replacement cycle, intervention
Standard hormone replacement cycle with estrogen and progesteron and a single dose of 0.1 mg triptorelin when the age of the embryo was 6 days
干预措施: Hormone replacement cycle and triptorelin acetate 0.1 mg (Drug)
结局指标
主要结局
Implantation rate
时间窗: five weeks after the embryo transfer
Pregnancy rate
时间窗: five weeks after the embryo transfer
Ongoing pregnancy rate
时间窗: ten weeks after the embryo transfer
次要结局
- hCG- level(14 days after thawing of the embryos)