Can MicroRNA's Predict Multicentricity in Breast Cancer?

Not Applicable

Completed

• Conditions: Multicentric Breast Cancer
• Interventions: Genetic: miRNA

• Registration Number: NCT04516330
• Lead Sponsor: Bezmialem Vakif University

Brief Summary

The aim of this study is to determine if microRNA's have role in predicting multicentricity in breast cancer. If a specific microRNA will be found to be related with multicentricity, it will help us to make appropriate decisions on the treatment of patients with multicentric breast cancer.

Detailed Description

In the study that will be held at Bezmialem Vakif University Medical Faculty, General Surgery Department, 20 unifocal and 20 multifocal breast cancer patients will be included. Tissues will be taken from both tumoral and normal breast tissues and they will be saved in microRNA later solution under -80°C. Then, 84 microRNA's will be studied in these tissues to see if they express any of these microRNA's.

Study Timeline

• Study First Submitted: 2013-12-10
• Study Start: 2014-02
• Primary Completion: 2016-02
• Study Completion: 2019-04
• Status Verified: 2020-08
• Study First Submitted QC: 2020-08-14
• Last Update Submitted: 2020-08-14
• Study First Posted: 2020-08-18
• Last Update Posted: 2020-08-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 57

Inclusion Criteria

1. Having breast cancer
2. Having no other malignancy
3. Female patient

Exclusion Criteria

1. Having other malignancy
2. Under 18 years old
3. Male patient

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
unifocal breast cancer	miRNA	patients having unifocal breast cancer
multicentric breast cancer	miRNA	patients having multicentric breast cancer

Primary Outcome Measures

Name	Time	Method
MicroRNA's in multicentric breast cancer	April 2014	Evaluation of 84 microRNA's in patients with multicentric breast cancer

Secondary Outcome Measures

Name	Time	Method
Treatment plan according to the detected microRNA in patients with multicentric breast cancer	April 2014	If a specific microRNA will be detected in patients with multicentric breast cancer, treatment plan will be individualized according to the detected microRNA

Trial Locations

Locations (1)

Bezmialem Vakif University; 🇹🇷 Istanbul, Turkey