Association between coronary microvascular dysfunction and glycemic variability
Not Applicable
- Conditions
- Ischemic heart disease
- Registration Number
- JPRN-UMIN000022404
- Lead Sponsor
- Chiba university Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who are on diabetes medication Acute coronary syndrome Significant coronary stenosis in the left anterior descending artery (LAD) Prior myocardial infarction in the LAD territory Severe skin disease Severe blood disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of the index of microcirculatory resistance (IMR) between high MAGE (mean amplitude of glycemic excursions) and low MAGE patients. MAGE is measured by a continuous glucose monitoring system (CGMS).
- Secondary Outcome Measures
Name Time Method Evaluating the relationship between coronary physiological measurements (IMR, coronary flow reserve [CFR], and fractional flow reserve [FFR]) and CGMS findings (mean glucose level, standard deviation of glucose levels, MAGE and hypoglycemia duration). Evaluating the relationship between coronary physiological measurements (IMR, CFR and FFR) and HbA1c, LDL cholesterol, HDL cholesterol, total cholesterol, triglyceride, body mass index, smoking status, renal function, hs-CRP, hs-troponin T and RHI. Comparison of coronary physiological measurements (IMR, CFR and FFR) between three groups: diabetes mellitus, impaired glucose tolerance and normal glucose tolerance.